2 PhD positions in Medical Science

reference number 313-718-10 2 PhD positions in Medical Science with an orientation towards Immunology See complete ad: http://www8.umu.se/umu/aktuellt/arkiv/lediga_tjanster/313-718-10.html Project description: Signal Transduction in Host-Microbial Interactions and Inflammation.The innate immune system provides the first line of defense against microbes and other foreign substances.Innate immune detections of and responsiveness to microbes is mediated by sets of receptors known as pattern recognition receptors (PRRs).PRRs detect highly conserved molecular structures on microbes called microbial associated molecular patterns (MAMPs).PRRs also detect molecular structures released by stressed or damaged host cells.These endogenous molecules are generally referred to as damage-associated molecular patterns (DAMPs).We are interested in understanding the mechanisms that govern the regulation of PRRs signaling pathways and how the breakdown of such regulation may lead to inflammation or impair anti-microbial host defenses.The studies will involve using various in vivo mouse models of inflammation and infection as well in vitro studies using a variety of techniques including flow cytometry, microscopy, lentiviral transduction, mass spectrometry, standard cell culture, protein biochemistry, and cell/molecular biology techniques.For more details please contact: Dr.Position description: Applicants are sought from highly motivated individuals from all over the world with at least a Masters degree or its equivalent in cell/molecular biology, immunology microbiology or a related discipline.Prior experience in active research lab will be an added advantage.The successful candidates will participate in activities provided by the Laboratory for Molecular Infection Medicine Sweden (MIMS) and therefore have a chance to interact with and learn various scientific and technical expertise from a dynamic team of researchers within the Umeå Centre for Microbial Research (UCMR) at Umeå University and the Nordic EMBL Partnership for Molecular Medicine.The position is available starting fall 2010 for a maximum period of 5 years.More information about MIMS on www.mims.umu.se/, The Nordic EMBL Partnership for Molecular Medicine (Nordic Nodes for Molecular Medicine) on www.embl.de/research/partnerships/nordic_nodes/index.html, and UCMR: www.ucmr.umu.se/ Application procedure: The application should be in English and should include a cover letter with a brief statement of research experience and interests, three reference names with contact details (phone numbers and e-mail addresses) and a CV.Documents sent electronically should be in MS Word or PDF format.We look forward to receiving your application!