Associate Director, Pathology - CVRM Safety

Are you an experienced medical/veterinary pathologist with expertise in toxicologic or disease area pathology? Do you also feel passionate to help deliver safe and effective new medicines to patients? Great, you have an exciting opportunity to join a team of highly skilled pathologists in CVRM Safety that work closely with scientists in the therapeutic area.

AstraZeneca is currently looking for a dynamic and experienced Medical/Veterinary Pathologist to join the Cardiovascular, Renal and Metabolism (CVRM) Safety team. The role is broad in scope and offers significant potential for professional development. The position could be located either in Gothenburg, Sweden; Cambridge, UK or Gaithersburg, US.

CVRM Safety is a leading safety organisation that develops and integrates innovative safety science with toxicology excellence to drive the design, selection and successful development of novel treatments for patients with cardiovascular, renal and metabolic diseases. We are a diverse international department across Sweden, UK and US that comprises toxicologists, pathologists, discovery safety specialists and experimental scientists. CVRM Safety sits within Clinical Pharmacology and Safety Sciences (CPSS), which contains all non-clinical safety functions that support the entire AstraZeneca portfolio.

As our Medical/Veterinary Pathologist you'll be expected to build effective cross-functional networks across CPSS and Early CVRM and actively seek collaborations on safety and efficacy (e.g. animal models, multimodal imaging, mechanistic toxicology and disease pathophysiology). You'll contribute to investigative safety and efficacy studies, ensuring timely delivery of high quality pathology data. You will work with novel treatment modalities, including but not limited to lipid nanoparticles and novel RNA therapeutics, to develop expertise in the pathological responses of organ systems to these agents.

What you'll do:
As a Pathologist in CVRM Safety, you will work closely with discovery safety specialists, toxicologists and disease area scientists, providing expert anatomic pathology support to CVRM drug projects across all development stages. With our expert Imaging & AI scientists you will explore use of artificial intelligence to drive quantitative pathology. You will peer review outsourced studies to ensure consistency and appropriate integration of pathology data within study reports and regulatory submissions. You are expected to provide a holistic view of translational safety and efficacy pathology and pathophysiology from animal to patient.

Essential requirements:

* MD or DVM Pathology degree.
* Significant experience in either toxicologic pathology or in a diagnostic area relevant to cardiovascular, renal or metabolic disease is an absolute requirement.

* Genuine interest in providing broad disease area, discovery and toxicologic pathology support and acting as a pathology representative on multiple drug development projects.
* Strong familiarity with complementary data sets (e.g. clinical pathology, IHC, ISH, MSI); ability to integrate pathology findings with a range of traditional and novel endpoints and provide contextualized interpretation for project teams.
* Highly effective written and oral communication skills with the ability to clearly convey complex pathology data to a wide range of stakeholders.
* Openess to champion the use of digital technology for all aspects of pathology and delivery of quantitative pathology data.

Desirable requirements:

* PhD in a subject relevant to toxicologic pathology or cardiovascular, renal or metabolic disease.
* Postgraduate pathology qualification (FRCPath, ESP, DACVP, DECVP or DJSTP).
* Scientific track record demonstrated by peer reviewed publications in high impact/high quality journals.
* Broad cross-species toxicologic pathology expertise with experience of histopathological evaluation and/or peer review of acute, subchronic, chronic and carcinogenicity studies.
* Strong academic network in either toxicologic pathology or a scientific area related to cardiovascular, renal and metabolic disease.

Why AstraZeneca?
When we see an opportunity for change, we seize it and make it happen, because any opportunity can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognizing their potential. Join us on our journey in finding new ways to work, pioneering cutting edge methods and bringing unexpected teams together!

If you this sound like the next position for you - apply today!

Welcome with you application no later than 14th March, 2021.

Where can I find out more?

* Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/
* Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en
* BioPharmaceuticals R&D: https://www.astrazeneca.com/r-d.html and https://www.youtube.com/watch?v=pmFx_jr2eFo