Associate Principal Scientist, Advanced Drug Delivery

At AstraZeneca we turn ideas into life changing medicines and strive to continuously meet the unmet needs of patients worldwide. Working here means being entrepreneurial, thinking big, and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you're our kind of person.

Pharmaceutical Sciences at AstraZeneca delivers the therapies of the future through scientific leadership in drug delivery, design of synthetic routes, and manufacturing of Active Pharmaceutical Ingredients (API) and drug products. Our portfolio of projects spans small molecules, peptides, oligonucleotides to RNA-based therapeutics across AstraZeneca's therapy areas. Advanced Drug Delivery (ADD) resides within Pharmaceutical Sciences with a mission to transform diverse modalities into investigational medicines.

We are now looking for a skilled and experienced Formulation Scientist to join us as Senior Scientist or Associate Principal Scientist, depending on your background and experience, in the New Modality Clinical Formulation team. The role sits within the ADD group at our vibrant R&D site in Gothenburg, Sweden

What You'll do

This is an exciting role where you will act as a key member of various project teams and provide your technical and scientific expertise into formulation design and development strategies within the new modality and advanced drug delivery portfolio of peptides, oligonucleotides and RNA based therapeutics, with emphasis on parental formulation development. You will be responsible for defining lead enabling formulations to ensure desired clinical performance from discovery to Phase II, including a strong contribution to CMC (Chemistry, Manufacturing, Control) aspects and deliveries. In addition, you will lead GxP/non-GxP drug product manufacturing and outsourcing activities and strategies. As such, we are looking for a candidate with previous solid experience in supporting drug projects in the clinical phase and who has a strong understanding of biopharmaceutics, formulation, and drug delivery across various modalities and dosage forms. The role will be expected to work cross-functionally supporting drug projects from early to late clinical phase and be involved in science & technology initiatives.

We are looking for you, who together with your team will make a difference for patients' lives every day. This through your ability to independently lead and achieve set goals within budget, time and to the right quality.

Essential for the role

* MSc or PhD degree in a relevant field (such as Pharmaceutics, Biotechnology, Chemistry or Drug Delivery) and industrial experience within the field of Pharmaceutical/Biotechnology Science.
* Strong background and know-how of clinical formulation development and design from the pharmaceutical industry, including in-depth knowledge of CMC deliveries and regulatory frameworks.
* Good understanding of formulation science, drug delivery and biopharmaceutics to enable mechanistic understanding of in vivo drug product performance.
* A history of leading GxP manufacturing activities and strategies, including reviewing and approving documentation such as Manufacturing Methods and Master Batch Records.
* Experience of initiating and maintaining outsourcing partnerships in the formulation and manufacturing area, including tech transfers, and reviewing data and documentation.
* Good understanding of the overall drug discovery and development process and an appreciation of how the Pharmaceutical Science field contributes to R&D.
* Ability and desire/willingness to effectively communicate, network and build collaborative relationships with partners across disciplines and cultures, internally and externally and independently lead and influence projects.

If your passion is science and you want to be part of a team that makes a bigger impact on patients' lives, then there's no better place to be.

With us there are many opportunities to develop yourself and your career. From our diverse portfolio and teamwork, to our cutting-edge innovations - it's a place for lifelong learning.

So, what's next?
Are you already imagining yourself joining us? Good, because we can't wait to hear from you!
For more information, please contact: Annette Bak, Executive Director at annette.bak@astrazeneca.com
Welcome with your application no later than August 8, 2021.



Additional information
BioPharmaceuticals R&D: https://www.youtube.com/watch?v=pmFx_jr2eFo
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
Culture and atmosphere of the Gothenburg site: https://www.linkedin.com/feed/update/urn:li:activity:6496327311678410752/