Associate Principal Scientist - Computational Chemistry

Do you want to join a world leading team in developing the next generation of respiratory medicines?



We are recruiting a highly motivated Computational Chemist to join our team as an Associate Principal Scientist, in the area of Respiratory & Immunology (R&I) at AstraZeneca R&D. This position is based in Gothenburg, Sweden.

AstraZeneca is committed to the development of the next generation of innovative respiratory and immunology medicines. The Computational Chemistry team leads efforts to expand the use of state of the art in silico methods for modelling, ligand design, property predictions and data analysis supporting the R&I drug discovery projects with a focus on small to medium sized molecules. The team operates in a highly cross disciplinary environment in close collaboration with scientists from the Chemistry, Bioscience, DMPK and Pharmaceutical Sciences departments to advance the R&I project pipeline.


What you'll do?
As a Computational Chemist you will have a profound impact on multiple projects across the R&I portfolio. You will work collaboratively with medicinal chemists and multidisciplinary teams to design compounds with improved potency, selectivity, activity and/or ADMET properties. By working simultaneously across multiple projects, in all discovery phases, you will identify and drive ligand design strategies and efficiently and proactively apply a full range of drug design and computational chemistry approaches to tackle complex problems within a project, delivering results to timelines that impact the design of compounds for synthesis and testing.

You will be accountable for identifying areas of scientific improvement within computational sciences and their potential for application to projects within AstraZeneca and will contribute to the development of new computational capabilities at AstraZeneca through collaboration with external groups or colleagues at other AstraZeneca sites. You publish original work and literature reviews in peer reviewed journals and at conferences, maintaining an up to date awareness of recent literature and current developments within the field.



Essential for the role
We are seeking an engaged computational chemist with a PhD (or equivalent experience) in computational chemistry, chemistry, pharmacology, or a related field with a strong computational background. Industry experience or a track record of applying innovative solutions with resulting impact in drug discovery project delivery is a plus, but not a must. The candidate is expected to have a high degree of independence and knowledgeable in a number of computer-aided drug design techniques to assist target identification and advancement of discovery programs.



We expect the right candidate to have;

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Solid knowledge of computational chemistry and medicinal chemistry concepts
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An understanding of how computational chemistry contributes to our drug discovery projects together with a good knowledge of the drug discovery process encompassing other disciplines, such as synthetic, structural and medicinal chemistry, DMPK, structural biology, biophysics, biological science etc.
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Experience in structure-based and ligand-based design techniques is essential, knowledge in scientific computing, and programming skills (e.g. Python, Perl, C, C++, Java) are desired.
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Specific knowledge in molecular modeling, specifically in molecular dynamics (MD) applications with a track record of applying these techniques to a relevant problem in the field is desired.
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Strong written and verbal communication skills and ability to work well in multidisciplinary project teams
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Excellent time management skills, forward planning and delivery focus



Why AstraZeneca?

At AstraZeneca we're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There's no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration, and always committed to lifelong learning, growth and development. We're on an exciting journey to pioneer the future of healthcare.



What's next?

We would like to know more about you. If you are interested, apply now!

We welcome your application (including CV and Cover Letter) no later than October 31, 2021. For more information about this position please contact: Dr. Christian Tyrchan, Medicinal Chemistry, BioPharmaceuticals Research and Early Development, Respiratory & Immunology, Christian.Tyrchan@astrazeneca.com



Where can I find out more?

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