Biologics Translational PKPD Modeling & DMPK Expert

Do you have a passion for PKPD modelling of antibody-based therapeutics and expertise in respiratory and immunology? Would you like to apply your knowledge in a global company that follows the science and turns ideas into life-changing medicines? Then you could be the new colleague we are looking for!



We currently have an exciting opportunity for a passionate PKPD modelling and DMPK Scientist to join our DMPK department as a Biologics Translational PKPD Modeling & DMPK Specialist within Early Respiratory and Immunology (R&I). The R&I DMPK department provides drug metabolism and pharmacokinetic, as well as translational PKPD modeling & simulation support to our portfolio. This position is located at AstraZeneca's vibrant R&D site in Gothenburg, Sweden.



At AstraZeneca Early Respiratory & Immunology (R&I), we're proud to have an outstanding workplace culture that encourages innovation and teamwork. We are united by our vision to push the boundaries of DMPK science to transform ideas into medicines for R&I patients. Employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.



What you'll do?
As a Biologics Translational PKPD Modelling & DMPK Specialist (Principal Scientist) you will have the opportunity to drive strategy and provide global leadership in PKPD science across our diverse portfolio, and act as role model, mentoring and guiding less experienced members of the team. You have in-depth knowledge of biologics drug discovery and a keen interest in understanding the translational PKPD of antibody-based therapeutics.

In the role you would provide projects with specialist modeling input into exploring PK/PD/Efficacy in pre-clinical models and use them to guide an understanding of the dosing across different patient populations.



Main Duties and Responsibilities:

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Be the key link between the leadership team and department in driving the translational PKPD strategy and leveraging modeling approaches in discovery projects towards human dose predictions
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Drive and embed strategic direction by developing and implementing best practices in supporting projects and share insight across the department
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Able to handle and balance the workload of multiple projects and efficiently manage your time and submit pragmatic solutions/strategies to ensure effective support of your projects
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Represent early R&I DMPK in projects and providing overall scientific leadership for cross functional collaborations involving DMPK
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Exploring the effects on target and pathway to understand the requirements for efficacy and set a candidate drug target profile (CDTP)
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Ensuring that translational PKPD approaches are embedded at the heart of project strategy and used to support design of appropriate experiments that are aligned to the strategy underpinning human dose prediction and providing input into exposure and pharmacodynamic (PD) biomarker based decision criteria
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Identify, champion and develop new ideas
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Offer a breadth of influence and impact across AstraZeneca DMPK
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Leading scientific discipline networks and acting as a focus for debate within the AstraZeneca scientific community
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Develop excellent working relations with key stakeholders within both DMPK and in the project teams, to ensure strategic alignment, strong cross discipline collaboration and communication.



Essential for the role

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PhD (or equivalent industrial experience) in a relevant field e.g. pharmacokinetics, pharmacology, biopharmaceutics etc.
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7 years of industry experience in Modeling & Simulation, ideally in preclinical/translational setting with a focus on biologics
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In-depth knowledge of therapeutic antibody drug discovery (incl. complex biologics, cell therapies, ADCs) and a keen interest in understanding the translational PKPD of antibody based molecules
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Experience of DMPK project facing role in pharmaceutical R&D with a variety of therapeutic antibody formats (e.g. mAbs, Fabs, bispecifics, ADCs etc).
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Track record of supporting PK, PKPD and TKPD aspects of projects, with a delivery focus and ability to meet timelines to pre-specified quality and cost
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Excellent interpersonal skills, and ability to work in cross-functional teams as well as strong scientific leadership skills
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Experience in defining quantitative modeling strategies across several therapeutic modalities (e.g. small molecules, oligonucleotides, peptides, proteins, antibodies)
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Hands on experience of using specialist tools such as WinNonLin/Phoenix, MATLAB, R, Berkely Madonna or similar



Why AstraZeneca?
At AstraZeneca we're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There's no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.



What's next!
If you are ready to make a difference - apply today, and we'll make it happen together! We welcome your application until March 15, 2024.

For more information about the position, please contact recruiting manager Nina Lawrence at Nina.Lawrence@astrazeneca.com