Biomarker Scientist

Biomarker team within Translational Science & Experimental Medicine (TS&EM) department

Hays Specialist Recruitment is now looking to recruit a Biomarker Scientist to join the Biomarker team for a 1-year contract assignment at AstraZeneca in Gothenburg.

Do you have expertise in Biomarker Discovery and Development in Cardiovascular, Metabolic and Renal Diseases? Would you like to apply your expertise at a company that are following the science and turn ideas into life changing medicines? Then you might be the one we are looking for!

We are now looking for a Senior Scientist, Biomarkers Discovery and Development to join the Biomarker team within Translational Science & Experimental Medicine (TS&EM) department in the Cardiovascular Renal and Metabolic Diseases (CVRM) therapeutic area at AstraZeneca in Gothenburg, Sweden.

CVRM is one of the three main therapeutic research areas within Innovative Medicines and Early Development, AstraZeneca's small molecule biotech unit that deliver candidate drugs into late-stage clinical development. CVRM TS&EM has the remit to bridge pre-clinical, early and late drug development by providing early target validation in humans and by driving precision medicine approaches through biomarker discovery and development based on understanding of human diseases and access to human patient samples.
The biomarker team has the accountability from pre-clinical to clinical biomarker delivery which include biomarker discovery for identification of target engagement and proof-of-mechanism biomarkers, generation of target related precision medicine hypothesis, analysis of explorative biomarkers in clinical projects, and for outsourcing biomarkers according to good clinical practice for internal decisions in clinical studies.

As a Senior Scientist in the Biomarker team, you will play a key role from preclinical to clinical biomarker delivery for progressing projects and science. This role will be primarily lab based and contribute to building the biomarker strategy i.e. driving biomarker discovery for identification of target-related biomarkers and precision medicine hypothesis generation. You will be responsible for delivering high quality and robust biomarker data package to support project progression across the CVRM project portfolio. This involves implementation of novel biomarker methods, e.g. ligand binding or mass spectrometry-based approaches using state of the art analytical techniques, biomarker analysis, reporting biomarker data and evaluation to the project teams

Collaboration is critical for successful delivery of drug projects and you will work closely with scientists/teams from a wide range of different functions within AstraZeneca. In this role, you will have the opportunity to try novel techniques and ideas for identification of new biomarkers.

Requirements

* Deep expertise in a range of analytical techniques for biomarker analysis (proteins, peptides, mRNA), specifically immunoassay/ELISA platforms (MSD, Luminex, SIMOA etc.), Taqman analysis and proteomics based on liquid chromatography mass spectrometry
* Experience in development of novel bioanalytical methods for quantification of biomarkers
* Experience in biomarker discovery and development within cardiovascular, renal and metabolism
* Ability to plan and report all work to appropriate standards (Good Laboratory Standard, GLS)
* Maintain awareness of relevant areas of research, drug discover/development technologies and regulatory requirements through reading scientific literature and guidelines
* Perform problem solving studies by identification of issues and where necessary designing experiments to overcome problems.
* Good project management and matrix leadership skills, ability to collaborate well cross functions
* Passion for delivering and promoting excellence in science.
* Excellent English communication skills, both verbal and written