Biomarker Scientist, AstraZeneca Gothenburg

Job description
Do you have expertise in Biomarker Discovery and Development in Cardiovascular and Metabolic Diseases? Would you like to apply your expertise at a company that are following the science and turn ideas into life changing medicines? Then you might be the one we are looking for!

We are now looking for a Senior Scientist, Biomarkers Discovery and Development to join the Biomarker team within Translational Science & Experimental Medicine (TS&EM) department in the Cardiovascular Renal and Metabolic Diseases (CVRM) therapeutic area. This is a consultant assignment at AstraZeneca in Gothenburg, Sweden.

CVRM is one of the three main therapeutic research areas within Innovative Medicines and Early Development, AstraZeneca’s small molecule biotech unit that deliver candidate drugs into late-stage clinical development. CVRM TS&EM has the remit to bridge pre-clinical, early and late drug development by providing early target validation in humans and by driving precision medicine approaches through biomarker discovery and development based on understanding of human diseases and access to human patient samples.

The biomarker team has the accountability from pre-clinical to clinical biomarker delivery which include biomarker discovery for identification of target engagement and proof-of-mechanism biomarkers, generation of target related precision medicine hypothesis, analysis of explorative biomarkers in clinical projects, and for outsourcing biomarkers according to good clinical practice for internal decisions in clinical studies.

Responsibilities
As a Senior Scientist in the Biomarker team, you will play a key role from preclinical to clinical biomarker delivery for progressing projects and science. You will be responsible for delivering high quality and robust biomarker data package to support project progression across the CVRM project portfolio. This involves implementation of novel biomarker methods, e.g. ligand binding approaches using state of the art analytical techniques, biomarker analysis, reporting biomarker data and evaluation to the project teams. You will also be responsible for outsourcing decision-making biomarkers (Good clinical practise, GCP) as well as explorative mechanistic biomarkers in the clinical projects. This process involves CRO selection, Due Diligence process, contracts, assay validation, and sample monitoring.

Collaboration is critical for successful delivery of drug projects and you will work closely with scientists/teams from a wide range of different functions within AstraZeneca as well as with external partners and collaborators. In this role, you will have the opportunity to try novel techniques and ideas required for progressing existing portfolio and novel science
The role requires interactive, effective communication providing clear data and interpretation to projects and contribution to the translational scientific strategy. You will make judgements about complex scientific information, developing innovative solutions and applying comprehensive cross-functional understanding.

Qualifications
Expertise in a range of analytical techniques for biomarker analysis, specifically, immunoassay/ELISA platforms (MSD, SIMOA, Luminex, Erenna, etc), mRNA analysis, flow cytometry etc.
Experience in development of novel bioanalytical methods for quantification of biomarkers
Plan and report all work to appropriate standards (Good Laboratory Standard, GLS) and Good clinical practise for outsourcing clinical biomarkers
Experience in biomarker discovery and development in cardiovascular, renal and metabolism.
Maintain awareness of relevant areas of research, drug discover/development technologies and regulatory requirements through reading scientific literature and guidelines
Perform problem solving studies by identification of issues and where necessary designing experiments to overcome problems.
Good project management and matrix leadership skills, ability to collaborate well cross functions
Passion for delivering and promoting excellence in science.
Excellent English communication skills, both verbal and written

For us, it is important that all competence and skills in the labor market are utilized. We welcome all applicants and strive for diversity.

Application
2021-02-11, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.


For more information: Eleonor Ehrman +46733434109

About the company
Randstad Life Sciences is specialized in competences within Life Science. As a consultant with us, you get a competitive salary, benefits and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many social activities.

Randstad Life Sciences is part of Randstad, the world leader in recruitment and consulting with operations in 38 countries. With this global network, in combination with our strong local foundation, we can offer a wide range of varied and developing assignments and jobs for you who are a specialist in life science. Our mission is to help you reach your true potential with your career in focus!