Biomarker Scientist, Biomarkers Discovery and Development

Do you have expertise in Biomarker Discovery and Development in Cardiovascular and Metabolic Diseases? Would you like to apply your expertise at a company that are following the science and turn ideas into life changing medicines? Then you might be the one we are looking for! We are now looking for a Senior Scientist, Biomarkers Discovery and Development to join the Biomarker team within Translational Science & Experimental Medicine (TS&EM) department in the Cardiovascular Renal and Metabolic Diseases (CVRM) therapeutic area at AstraZeneca in Gothenburg, Sweden.

About the role:
CVRM is one of the three main therapeutic research areas within Innovative Medicines and Early Development, AstraZeneca’s small molecule biotech unit that deliver candidate drugs into late-stage clinical development. CVRM TS&EM has the remit to bridge pre-clinical, early and late drug development by providing early target validation in humans and by driving precision medicine approaches through biomarker discovery and development based on understanding of human diseases and access to human patient samples.

The biomarker team has the accountability from pre-clinical to clinical biomarker delivery which include biomarker discovery for identification of target engagement and proof-of-mechanism biomarkers, generation of target related precision medicine hypothesis, analysis of explorative biomarkers in clinical projects, and for outsourcing biomarkers according to good clinical practice for internal decisions in clinical studies.

As a Senior Scientist in the Biomarker team, you will play a key role from preclinical to clinical biomarker delivery for progressing projects and science. You will be responsible for delivering high quality and robust biomarker data package to support project progression across the CVRM project portfolio. This involves implementation of novel biomarker methods, e.g. ligand binding approaches using state of the art analytical techniques, biomarker analysis, reporting biomarker data and evaluation to the project teams. You will also be responsible for outsourcing decision-making biomarkers (Good clinical practise, GCP) as well as explorative mechanistic biomarkers in the clinical projects. This process involves CRO selection, Due Diligence process, contracts, assay validation, and sample monitoring.

Collaboration is critical for successful delivery of drug projects and you will work closely with scientists/teams from a wide range of different functions within AstraZeneca as well as with external partners and collaborators. In this role, you will have the opportunity to try novel techniques and ideas required for progressing existing portfolio and novel science. The role requires interactive, effective communication providing clear data and interpretation to projects and contribution to the translational scientific strategy. You will make judgements about complex scientific information, developing innovative solutions and applying comprehensive cross-functional understanding.


Requirements for the role:
• Expertise in a range of analytical techniques for biomarker analysis, specifically, immunoassay/ELISA platforms (MSD, SIMOA, Luminex, Erenna, etc), mRNA analysis, flow cytometry etc.
• Experience in development of novel bioanalytical methods for quantification of biomarkers
• Plan and report all work to appropriate standards (Good Laboratory Standard, GLS) and Good clinical practise for outsourcing clinical biomarkers
• Experience in biomarker discovery and development in cardiovascular, renal and metabolism.
• Maintain awareness of relevant areas of research, drug discover/development technologies and regulatory requirements through reading scientific literature and guidelines
• Perform problem solving studies by identification of issues and where necessary designing experiments to overcome problems.
• Good project management and matrix leadership skills, ability to collaborate well cross functions
• Passion for delivering and promoting excellence in science.
• Excellent English communication skills, both verbal and written


About AstraZeneca:
At AstraZeneca, we turn ideas into life changing medicines and strive to continuously meet the unmet needs of patients worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person.


Are you ready to bring new ideas and fresh thinking to the table? Brilliant!
We have one seat available and we hope it’s yours.
For further details around this 12-months consulting position you are welcome to contact Martin Kurzwelly at martin.kurzwelly@poolia.se.