Biopharmaceutics Expert in Oral Drug Delivery

Pharmaceutical Sciences at AstraZeneca delivers the therapies of the future through scientific leadership in drug delivery, design of synthetic routes, and manufacturing of Active Pharmaceutical Ingredients (API) and drug products. Our portfolio of projects spans small molecules, peptides, oligonucleotides to RNA-based therapeutics across AstraZeneca's therapy areas. Advanced Drug Delivery (ADD) resides within Pharmaceutical Sciences with a mission to transform diverse modalities into investigational medicines.

We now seek a talented, motivated biopharmaceutics scientist at a Senior Scientist level to join our Small Molecule Preformulation and Biopharmaceutics team in Gothenburg, Sweden. The remit of the cross-functional team is to deliver small molecule formulation and analytical solutions up to candidate drug delivery and GLP tox, as well as biopharmaceutics expertise from discovery up to Phase II.

This is an exciting role where you as a Biopharmaceutics Expert are anticipated to provide biopharmaceutics input into primarily oral development projects and participate in method development and research projects within the area of oral biopharmaceutics. This role is also considered a global role, as the biopharmaceutics input will cover projects within the oncology field, where project team members can be located globally with a primary focus in UK and US.



Typical accountabilities for the role

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Responsibilities for influencing design and selection of lead compound based on biopharmaceutics properties in collaboration with cross-functional networks such as chemistry, safety and pharmacokinetic specialists.
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Expected to influence formulation design and development strategies for projects to ensure desired pre-clinical and clinical performance targets through collaboration in multidisciplinary teams consisting of formulators, analysts, solid state and material science experts
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Expected to have/develop a holistic view of CMC activities as well as have knowledge of other scientific disciplines within BioPharmaceuticals R&D, and contributes to the delivery of innovative and differentiated strategies that balance scientific risks against return on investment based on multidisciplinary input
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Executes and aids in development of appropriate in vitro tests, as well as guides in vivo methodologies to predict product performance, including dissolution, absorption, permeability and intestinal precipitation tests to support drug development
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Predicts pre-clinical and clinical performance of drug products based on in vitro as well as in vivo data using mechanistic in silico models
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Supports design of clinical studies and clinical bridging strategies with a line-of-sight perspective either independently or with the aid of senior experts dependent on level of expertise in the field of biopharmaceutics.
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Participates in cross-functional and external networks to ensure biopharmaceutics related science and project input is up-to-date with current developments in the field, and shares the knowledge in and outside of own function
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Ensures that clinical reports, scientific presentations, publications and other outgoing documents are produced with high quality, and produce these through collaboration with appropriate collaborators within and outside of AstraZeneca
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Ensures that developed strategies are in line with regulatory guidances (e.g. ICH, EMA, FDA)
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Ensures own work, and the work of others, is performed in accordance with appropriate Safety, Health & Environment (SHE), quality and compliance standards, e.g. Good Laboratory Practice (GLP)



Education and work history to fit the role

We are looking for candidates with

* Preferably a PhD in a relevant discipline (such as Biopharmaceutics, Pharmaceutics, Pharmacokinetics or Drug Delivery) or equivalent industrial experience within oral pharmaceutical drug development
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A strong understanding of biopharmaceutics, physical chemistry, biology and pharmacokinetics to enable a mechanistic understanding of in vivo drug product performance
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Experience of presenting scientific findings in publications, presentations and networking activities with ability to communicate and write proficiently in English.
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Practical experience of using in vivo, in vitro and in silico methodologies to understand drug product performance and aid in product development
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Good understanding/knowledge of the overall drug development process and knowledge of what CMC attributes that make this process successful



Additional capabilities desirable for the role

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Innovative, driving for scientific excellence with a continuous improvement mind-set
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Excellent communication and stakeholder management skills, and the ability to discuss complex ideas in a simple, easy to understand way
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Ability to tackle complex scientific problems and troubleshooting, and independently lead and influence projects



So, what's next?

For more information about the positions, please contact:

Sara Carlert, Team Leader, Advanced Drug Delivery, at Sara.Carlert@astrazeneca.com

Are you already imagining joining our team? Good, because we can't wait to hear from you! Welcome with your application no later than 5 June, 2022. We will review the applications continuously so please apply as soon as possible.