Cardiovascular Renal and Metabolism (CVRM) in Vitro Research

Job description
Cardiovascular Renal and Metabolism (CVRM) Research – Metabolism In Vitro Team

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because an opportunity no matter how small can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognising their potential.

The AstraZeneca CVRM Research group in Gothenburg is seeking to recruit a high calibre scientist to enable progression of a growing drug project portfolio. Highly motivated scientists are encouraged to apply for the opportunity to join our team of professionals who are passionate about advancing science, to discover and develop novel therapeutics that will benefit patients.

Responsibilities
Role Overview
You will play an active role in implementing and executing scientific research within a CVRM Metabolism project, enabling studies aimed at exploring disease modifying mechanisms linked to pharmacological inhibition of the biological target of interest. This is a "hands-on," laboratory based scientific and technical role in our in vitro metabolism team supporting projects from target validation to lead optimisation phases.

Role Specifics
This position will be laboratory based and you will be responsible for several technical and experimental processes to support the CVRM Research group.

Responsibilities
Responsibility for design, execution and analysis of in vitro and ex vivo assays.
Communicate results, conclusions and recommendations to colleagues, line manager and the project team.
Record experiments in lab books and databases.
Play a leading role in assay development and optimisation of in vitro assays.
You would report to an expert member of staff and would be encouraged to be able to plan your daily work within direction set by your supervisor.

You will:
Be asked to provide interpretation of assay results.
Work within a line and/or matrix/project team.
Demonstrates scientific rigor in assessing own data and that of others.


Qualifications
Essential Requirements
Be a "hands-on" expert with in vitro models and methodologies.
Ability to develop new methods, technologies, and processes
Enthusiasm for laboratory work, scientific curiosity.
Experience in running in vitro biochemical and cellular assays to provide potency and activity readouts, including use of primary and recombinant cell lines.
Significant cell culture experience.
Experience with disease relevant cell types such as primary hepatocytes or hepatocyte-like cell lines in 2D cultures.
Experience with ex vivo analysis of blood/tissue samples (including qPCR for gene expression, Western blots, and ELISA).
Experience in data analysis and interpretation and enthusiasm for problem solving for scientifically challenging work.
Demonstrable ability to work within a line and/or matrix/ cross-functional project team.
Strong interest in providing materials and data for scientifically challenging work.
Strong organisational, time management and communication skills.
Strong, demonstrable analytical ability.
Good oral and written communications skills.


Desirable  Requirements
Background in metabolic disease research areas.
Experience with 3D spheroid models and expertise to establish and evaluate models of liver disease in the context of steatosis and fibrosis.
Knowledge and experience with automation and robotic methods for increasing throughput and medium to high density microtitre plate technologies.
An understanding of biological sciences, familiarity with the drug discovery process.
Experience working in pharmaceutical or biotech environment.


Behavioural competencies
Hard working, organised, balanced and meticulous with an ability to work well under pressure.
Adaptable and a team player with a conscientious attitude and enthusiasm.
Desire to learn and build on the role.
Education
Degree in one of the Life Sciences disciplines and equivalent post-graduate or industry experience.


Application
Deadline: 2022-01-12, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.

For more information, please contact Kerstin Karlsson, kerstin.karlsson@randstad.se or Veronika Knudsen, veronika.knudsen@randstad.se 

About the company
 Randstad Life Sciences is specialized in competences within Life Science. As a consultant with us, you get a competitive salary, benefits and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many social activities.

Randstad Life Sciences specializes in the field of science and is part of Randstad, the world leader in recruitment and consulting with operations in 38 countries. With this global network, in combination with our strong local foundation, we can offer a wide range of varied and developing assignments and jobs for you who are a specialist in life science. Our mission is to help you reach your true potential with your career in focus!