Clinical Pharmacometrician

Do you have expertise and experience in mathematical modelling and simulation, PKPD and its application in drug development? Do you also feel passionate about the possibilities of science to change lives? Perfect, your next challenge might be this role at AstraZeneca!

This is an opportunity for a hardworking and engaged individual to join our growing Clinical Pharmacology and Quantitative Pharmacology team at AstraZeneca in Gothenburg and develop as a Clinical Pharmacometrician supporting large and small molecule projects across full development within the therapy area of Respiratory & Immunology.

AstraZeneca is a world-leading pharmaceutical company, we focus on discovering and developing medicines that make a real difference to millions of patients. Within the Clinical Pharmacology and Safety Sciences (CPSS) function, we have a state-of-the-art quantitative clinical pharmacology group with a diverse and uniquely skilled team of clinical pharmacometricians and clinical pharmacology scientists. Gothenburg is a key research and development location for our Respiratory & Immunology and Cardiovascular, Renal and Metabolic therapeutic areas.

You'll thrive in an environment that inspires innovation, encourages multidisciplinary team-working and collaboration with academia, and rewards original scientific thinking.

What you'll do:
You will work closely with clinical pharmacology scientists, physicians and other scientists and apply modelling to support the design and interpretation of clinical studies and influence key decisions in early and late clinical development.

The work includes integration of relevant data, such as dose information, pharmacokinetics, biomarkers and clinical endpoints within and across studies, compounds and development stages. Supporting informative trial designs using simulations and efficient modeling statistics is an important focus area for us. In collaboration with clinical pharmacology scientists, you'll represent Clinical Pharmacology and Quantitative Pharmacology and be responsible for identifying and executing modelling to support model informed drug development. You will communicate your findings to other scientists within and outside of AstraZeneca and publish them in peer reviewed journals.

Essential for the role:

* PhD degree preferred or equivalent (M.Sc/Pharm.D.) with relevant experience required
* Quantitative modelling skills, e.g. knowledge in mathematics and statistics applied to life sciences
* Working knowledge of pharmacokinetics and its clinical application
* Background and an understanding of clinical pharmacology aspects of drug development, preferably in both the small and large molecule setting
* Experience with PK/PD analysis and statistical (pharmacometric) tools such as Phoenix Winnonlin, Nonmem, R
* Biological understanding of disease and drug action
* Good oral and written communication skills
* 0-3 years' relevant experience required for an associate clinical pharmacometrician position;
3-6 years' relevant experience required for a clinical pharmacometrician position

Desirable for the role:

* Recognized scientific expertise demonstrated by scientific publishing in the field of clinical pharmacology
* Early or late phase clinical development experience/awareness.

Why AstraZeneca?
At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognizing their potential. Join us on our journey of building a new kind of organisation to reset expectations of what a bio-pharmaceutical company can be. This means we're opening new ways to work and bringing unexpected teams together.

If this sounds like the job and workplace for you - apply today!

Welcome with your application no later than 17th November.

About the Gothenburg site:
Our Gothenburg site is one of AstraZeneca's three strategic science centers. We thrive in a multinational environment working cross-functionally across the globe with AstraZeneca colleagues as well as academic and industry partners. Our way of life is to foster a working environment that nurtures, collaboration, openness and innovation. Therefore, we have created space for meetings, socializing and relaxation, where spontaneous meetings can give birth to new innovations. The unexpected ideas or thoughts that can come from a chat over something as simple as a cup of coffee or a stroll on our "walk and talk" meeting trail.

Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/