Computational chemist specialized in Structure-Based Drug Design

Computational chemist specialized in Structure-Based Drug Design



Are you a scientist with a passion for computational chemistry? Then, you might be who we are looking for. We are working with drug discovery from the idea stage to clinical candidate in an efficient and multi-disciplinary research environment. Join us and help us develop new therapies for treating cancer! (This is a one-year full-time temporary position to cover parental leave.) 


SPRINT BIOSCIENCE IN SHORT


Sprint Bioscience develops small-molecule drug projects with a focus on oncology. With fragment-based drug design methods, advanced technical approaches, and leading specialists, we develop the drugs of the future - from the idea stage to a clinical candidate with the goal set at being "First-in-Class". 


Our business model is to identify and develop drug projects and license these in the preclinical phase to partners in the pharma industry for further development.  We choose projects with the greatest technical and commercial potential for success. 


About 35 committed employees work closely together in a multidisciplinary environment with cutting-edge science. We collaborate with academic and industrial partners from all over the world. 


We are situated in tailor-made premises in Flemingsberg, Huddinge, 20 minutes by train from Stockholm City.


ABOUT THE POSITION


You will be a member of the Structure-Based Drug Design team, consisting of dedicated scientists with expertise in the different areas related to computational chemistry and structural biology.


We work in efficient and dynamic project teams composed of members of all our disciplines (biochemistry, biophysics, cell, biology, computational chemistry, medicinal chemistry, structural biology). As such, you will have the opportunity to work on multiple projects in parallel, in constant interaction with members of the other scientific teams. You will be provided with the opportunity to develop both within and outside your discipline. 


You will bring your expertise, your passion, and your creativity to a role where you will be: 


Developing and applying computational models (docking, MD, QM, pKa, …) for protein-ligand (small molecules) complexes and ligands.   
Delivering high-quality evaluations of design ideas and prioritization of compounds for synthesis. 
Analyzing SAR
Design new compounds to improve specific properties (affinity, selectivity, ADME, …)
Managing project data.
Supporting other members of the team and solving challenges together.
Implementing new workflows and new methods for computational chemistry and structure-based drug design in general


WHO YOU ARE


To be successful in this position you need:


M.Sc. or Ph.D. in computational chemistry or related field.
Expertise in computational chemistry, in particular modeling of protein-ligand (small molecules) complexes and/or ADME parameters and design of small molecules inhibitors.
A passion for structure-based drug design.
To be accurate and organized.
A collaborative mindset.
Excellent communication skills in written and spoken English. 


If you also have experience in the following fields, it will be considered as beneficial: 


·       Good knowledge in medicinal chemistry
·       Fragment-based drug design
·       Good knowledge in structural biology
·       Automation and scientific programming


HOW TO APPLY


Are you the colleague we are looking for? Please send in your application no later than 11 August 2024. Applications will be continuously reviewed. Curious about what it is like to work at Sprint Bioscience? https://www.sprintbioscience.com/en/career/what-do-our-employees-say/


We refrain from contact by recruitment companies regarding this appointment.