Crystallographer/Solid-state scientist - EPDM

Pharmaceutical Sciences at AstraZeneca deliver the therapies of the future through scientific leadership in drug delivery, design of synthetic routes, and manufacturing of Active Pharmaceutical Ingredients (API) across all the AstraZeneca therapy areas. Our vision is to be "pharmaceutical science leaders, creating innovative and cost-effective solutions, shaping the diverse therapies of the future".



The role

We're now looking for talented and motivated crystallographers/solid-state scientists to join our analytical and solid state characterization team within Early Product Development and Manufacturing (EPDM) in Gothenburg.

You would join a highly collaborative team and help us deliver the solid-state science to product development within the early portfolio from discovery up to phase II. The successful applicant candidate will have the opportunity to work in a highly science driven environment using industry leading tools and instrumentation. You will become a core member of the global Solid-state skill area which is responsible for ensuring suitable physical form screening, selection and control within drug substance and product.

In this role, you will get the opportunity to apply your excellent crystallography and solid-state expertise to the drug projects you are working in, contributing to the progression of these projects and drive the scientific development within the field of solid-state science at AstraZeneca.



Main accountabilities in the role:

*

Provide expertise in small molecule X-ray diffraction to allow identification, characterization and selection of crystal forms.
*

Solving small molecule crystal structure through single crystal X-ray diffraction to underwrite solid form selection. This include ability to resolve complex crystal structures such as highly disordered, twin and modulated structures.
*

Maintain and foster development of software for visualization and modelling of crystal structures including structural informatics and database.
*

Apply structural knowledge to enhance solid form selection and particle engineering in collaboration with internal and external experts.
*

Work with external facilities such as synchrotron, microED (single crystal electron diffraction), single crystal diffraction service equipped with rotating anode source for small molecule X-ray crystallography.
*

Responsible for ensuring suitable physical form screening, characterisation, form selection and control within drug substance and product.
*

Drive solid state skill area in projects and work closely with analytical, formulation, and biopharmaceutics scientists to drive science and innovation.
*

Drive and lead science personally and within the department, manage external collaborations and publish novel work in peer reviewed journals.



Do you have the essential qualifications?

We believe you have a PhD in chemical crystallography with proven ability in small organic compounds and have a good knowledge in general solid-state chemistry, physical chemistry or related discipline. In-depth knowledge and experience in obtaining, solving and refining crystal structures from single crystal X-ray diffraction including ability to operate different crystallographic interfaces such as CrysAllis Pro, Shelx (e, s, t, le) and Olex2 is important for the role. Knowledge about solving crystal structures from powder will be advantageous.

The perfect candidate would be a driven experimentalist, with a passion to deliver highly relevant knowledge to those around you. Experience in the screening and characterisation of solids (e.g. X-ray diffraction, spectroscopy, thermal analysis, microscopic techniques, moisture sorption etc.), a good awareness of analytical methodology and an enthusiasm for laboratory-based work are key essentials for the role.

We believe you have experience/knowledge or a keen interest in the field of simulation or predictive science and a good understanding of the principles and concepts of crystallisation. In depth understanding of how the physicochemical and solid-state properties of a drug, effect the drug product development, e.g. material science and manufacturing processes is advantageous.



Skills and Capabilities:

*

Creativity and innovation, built on sound technical knowledge and problem-solving skills are required in order to deliver robust physical forms which meet the needs of the patient.
*

Assess, review and report data from own work, with a clear understanding of its reliability and interpret findings and draws authoritative conclusions and recommendations so that their significance can be appreciated. Present information for discussion in multi-disciplinary project teams.
*

Work as a member of cross-functional teams, with a large degree of independence representing own department or area of expertise.
*

Ability to drive and lead science personally and within the department and manage external collaborations.
*

Excellent communication, team working, networking and leadership skills & ability to lead and inspire colleagues.



So, what's next?

Welcome with your application (CV and cover letter) no later than December 16 2022. We will review the applications continuously so please apply as soon as possible.