Director for Mechanistic Biology and Profiling Team in Sweden

Do you possess leading expertise within pharmacology and have a passion for drug discovery? Are you a dedicated and experienced enzymologist/in vitro pharmacologist? Would you like a role where your expertise, as well as your leadership skills, will be highly appreciated? Welcome to join us at AstraZeneca!

We are currently recruiting a Director in the Mechanistic and Structural Biology (MSB) department in Gothenburg, Sweden to lead a Mechanistic Biology and Profiling (MBP) team. In this role, you will pursue world-class medicines in new ways working with exceptionally skilled people from all over the global AstraZeneca R&D organisation.

MSB is a global multidisciplinary function that includes expertise in pharmacology, biochemistry, enzymology, cell biology, structural biology and a broad range of biophysical methods to support the progression of compounds from hit to candidate.

Inclusion and diversity are fundamental to the success of our company, because innovation requires breakthrough ideas that only come from a diverse workforce empowered to challenge conventional thinking. If you're inspired by the possibilities of science to make a difference and ready to discover what you can do - join us.

What you will do:
As Director within MSB you will lead a high-performing team to provide early, impactful mechanistic insight to projects across CVRM, R&I and NS therapeutic areas, through a combination of in vitro enzymology, pharmacology, and quantitative cell biology. You will be accountable for establishing and driving capabilities to support the AZ Oligonucleotide Discovery platform and act as point-of-contact for oligonucleotide based projects' lead generation planning. You and your team will generate pre-clinical pharmacology data to profile proprietary compounds and underpin SAR development as well as investigate compounds' detailed mechanism of action to predict and understand efficacy and novel therapeutic modalities.

You will represent the department across a broad range of drug discovery projects and global initiatives as well as externally. You will drive scientific and technical innovation, including through external collaborations and partnerships. You will participate in setting and maintaining the strategic direction, scientific quality and efficiency of the global MSB department, and contribute to the development and execution of DS and AZ's global research strategies.

Essentials in the role:

* PhD/Post-doc or equivalent in the fields of Pharmacology / Cell Biology / Biochemistry or related disciplines with 8+ years' experience ideally gained in a drug discovery environment.
* Comprehensive understanding of the quantitative biology-based disciplines (enzymology, pharmacology).
* Extensive experience and expertise in screening, assay design and technology, mechanism of action studies, statistical tools and advanced data analysis ideally gained in a drug discovery setting.
* Proven expertise in oligonucleotide research and in vitro pharmacology.
* Experience in managing teams of highly qualified personnel working in related scientific disciplines.
* Proven track record of career progression, and external scientific reputation gained through professional recognition, conference presentations and publications.
* Experience in establishing and leading external collaborations and technology change projects to advance or establish new capabilities.
* Track record of delivering results across a diverse project portfolio by driving strategic, scientific, financial and people performance.

We also see you as a passionate and energetic leader with ability to articulate and communicate a vision, set direction and inspire commitment towards your team to together create drug discovery projects' success.

Desirable in the role:

* Generates exceptional results by influencing, driving performance and collaborating across project and country boundaries.
* Demonstrated ability to initiate and successfully deliver value from external collaborations.
* Knowledge of the competitive landscape in the fields of Oligonucletide Therapeutics, Pharmacology, Cell Biology, Biochemistry and Enzymology and related cutting-edge technologies applied to drug discovery.
* Good working knowledge of all the disciplines and areas of responsibility of MBP Sweden.

Why AstraZeneca?
Be part of a dedicated Research & Development team. Fuelled by our commitment to help more patients, strengthen our pipeline and grow our area. Be encouraged and supported to think creatively in our dynamic environment. Here we are free from fear of failure, free to ask the right questions and make bold decisions.

Does this sound like your next challenge and place to work? Apply today!

We look forward to your application, but no later than 25th July, 2022. For more information about the position please contact Maria Flocco - VP Mechanistic & Structural Biology at maria.flocco(at)astrazeneca.com.

Additional information:
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
Make a move to Global Gothenburg: https://www.youtube.com/watch?v=c-Iqbb4aw38
About BioPharmaceuticals R&D: https://www.astrazeneca.com/r-d.html

NOTE - Due to our summer vacation period in Sweden during July-August, the screening process may take a bit longer than usual. Thanks for your understanding and we will get back to you as soon as possible when we are back at work.