Director Pathology - Cardiovascular, Renal and Metabolism

Are you an experienced medical/veterinary pathologist with expertise in toxicologic or disease area pathology to help us deliver safe and effective new medicines to patients? This is an exciting opportunity to join a team of highly skilled pathologists in CVRM to continue to push the boundaries of science.

AstraZeneca is looking for a dynamic and experienced Medical/Veterinary Pathologist to support our work in the Cardiovascular, Renal and Metabolism (CVRM) disease area. This role is broad in scope and offers significant potential for professional development - and you will be placed either in Gothenburg, Sweden or Cambridge, UK.

Pathology works closely with CVRM Safety which is a leading safety organisation that develops and integrates innovative safety science with toxicology excellence to drive the design, selection and successful development of novel treatments for patients with cardiovascular, renal and metabolic diseases. The CVRM Safety department works across Sweden, UK and US and covers all aspects of toxicology and pathology support to the disease area. Pathology and CVRM Safety sit within Clinical Pharmacology and Safety Sciences (CPSS), which contains all non-clinical safety functions that support the entire AstraZeneca portfolio.

What you'll do:
As a Pathologist in CVRM, you will work closely with discovery safety specialists and toxicologists as well as disease area scientists, providing expert anatomic pathology support to multiple CVRM drug projects across all development stages. You'll contribute to the design and assessment of investigative safety and efficacy studies, ensuring timely delivery of high quality pathology data. In addition, you'll provide pivotal pathology support to AstraZeneca's new modalities team and develop expertise in the pathological responses of organ systems to novel treatment modalities including novel RNA therapeutics and regenerative medicine projects.

Working closely with our expert team of Imaging & AI scientists, you will together develop novel applications in image analysis and explore use of artificial intelligence to drive translational quantitative pathology. We also rely on you to build effective cross-functional networks across CPSS and Early CVRM and with a curious mind seek opportunities for collaboration on safety and efficacy (e.g. animal model development, multimodal and in vivo imaging, mechanistic toxicology and disease pathophysiology). Peer review of outsourced toxicology studies is an important part of your responsibility. For individual drug projects, you'll ensure consistency of CRO pathology outputs across toxicology studies and appropriate integration of pathology data within study reports and regulatory submissions. You are expected to provide a holistic view of translational safety and efficacy pathology and pathophysiology from animal to patient.

Essential in the role:

* MD or DVM Pathology degree.
* Significant experience in either toxicologic pathology or in a diagnostic area relevant to cardiovascular, renal or metabolic disease is an absolute requirement.
* Genuine interest in providing broad disease area, discovery and toxicologic pathology support and acting as a pathology representative on multiple drug development projects.
* Strong familiarity with complementary data sets (e.g. clinical pathology, IHC, ISH, MSI); ability to integrate pathology findings with a range of traditional and novel endpoints and provide contextualised interpretation for project teams.
* Highly effective written and communication skills with the ability to clearly convey complex pathology data to a wide range of stakeholders.
* Willingness to embrace and champion the use of digital technology for all aspects of pathology and delivery of quantitative pathology data.

Desirable in the role:

* Postgraduate pathology qualification (e g FRCPath, ESP, DACVP, DECVP or DJSTP).
* PhD in a subject relevant to toxicologic pathology or cardiovascular, renal or metabolic disease.
* Broad cross-species toxicologic pathology expertise with experience of histopathological evaluation and/or peer review of acute, subchronic, chronic and carcinogenicity studies.

Why AstraZeneca?
We continually push the boundaries of science to deliver medicines that treat diseases across our main therapy areas. Through our integration with Alexion, this now includes expanding the limits of scientific research to better understand rare diseases and to discover new life-changing treatments for them.

So, what's next? If this sound like your next challenge - apply today! We welcome your application from today 9th February, but send it to us no later than the 13th March, 2022.

For more information about this opening please reach out to Hiring Manager Magnus Söderberg at magnus.soderberg(at)astrazeneca.com

Additional information:
AstraZeneca Gothenburg: https://www.astrazeneca.com/our-science/gothenburg.html
AstraZeneca Cambridge: https://www.astrazeneca.com/our-company/our-locations/cambridge.html
About BioPharmaceuticals R&D: https://www.astrazeneca.com/r-d.html

This position entitles competitive salary and benefits package on offer.