Director, Safety and Mechanistic Pharmacology

Are you an expert within Safety Pharmacology with extensive knowledge in designing and interpreting high quality studies, translating scientific findings into applicable information in a drug development environment? Be part of a dedicated Research & Development team. Fuelled by our commitment to help more patients, strengthen our pipeline and grow our area.

To help deliver our growing portfolio, we are currently seeking an experienced Safety Pharmacologist to join the Safety & Mechanistic Pharmacology team at AstraZeneca as a Director, Safety and Mechanistic Pharmacology. You will be located on our vibrant R&D site in Gothenburg, Sweden.

The Regulatory Toxicology and Safety Pharmacology team sits within CPSS and plays a central role in progressing a rich and diverse pipeline comprising many different modalities across a lot of our therapeutic areas. We work collaboratively to deliver safety science from early discovery through clinical development, with emphasis on the science and studies required to enable the clinical development of new medicines. Clinical Pharmacology & Safety Sciences (CPSS) is a multi-faceted department which underpins AstraZeneca's Biopharmaceutical and Oncology Portfolio from target selection through to Life-cycle management.

What you will do:
In this role you will be responsible for defining the overall Safety Pharmacology strategy for the Cardiovascular, Renal and Metabolic (CVRM) portfolio and for supporting individual drug projects with Safety Pharmacology expertise. Establish and drive partnerships within and beyond AstraZeneca to address the challenges presented our extensive portfolio of innovative drug projects is an important part of the role.

You will use your scientific depth to develop and implement strategies as well as hands on tools for safety pharmacology within drug development projects. Your interpersonal, networking and partner management skills will be essential to become successful in this role. We expect you to collaborate with other experts across the development chain, to deliver safety pharmacology packages that meet time, cost and quality standards.

Your main tasks will include:

* Working at the efficacy; safety interface, develop strategies to optimize safety profiles of new medicines in patients.
* Develop patient-centric safety pharmacology risk assessment strategies applicable to novel therapeutic modalities, where conventional approaches may not be appropriate or possible.
* Design fit for purpose safety pharmacology packages for projects.
* Author non-clinical safety pharmacology sections of regulatory submission documents and engage with regulatory authorities to secure approval of IMPD/IND and MAA/NDA submissions.
* Build CPSS's reputation as an industry leading function through high impact publications and partnerships that extend safety pharmacology beyond the boundaries defined by ICH S7A and S7B.

Essential in the role:

* Experienced scientist with a PhD (or equivalent experience) in pharmacology, toxicology, pathology or a related Natural Science field.
* Extensive experience in design and interpretation of high quality studies, translating scientific findings into applicable information in a drug development environment.
* Familiar with pharmacokinetic-pharmacodynamic and systems pharmacology approaches.
* Validated ability to run a large portfolio of projects including prioritize activities in a matrix environment.
* Understanding of the external factors that shape the scientific and regulatory landscapes relevant to Safety Pharmacology.
* Proven strong scientific track record and problem-solving capabilities.

We also believe that the successful candidate have high ability to communicate and present your work in a natural and clear way and enjoy working across multi-disciplinary teams with efficiency.

Desirable in the role:

* Experience of Safety Pharmacology in drug discovery and development, with exposure to non-clinical safety assessment in a project setting.
* In depth knowledge of cardiac function, ECG and imaging modalities.
* Diplomat of Safety Pharmacology, DABT or ERT accreditation.

Why AstraZeneca?
Thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment.

So, what's next! If this sounds like the place and job for you - apply today! We look forward to find out more about you - make sure you apply no later than the 10th July, 2022.

Additional information:
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
Make a move to Global Gothenburg: https://www.youtube.com/watch?v=c-Iqbb4aw38