Discovery Safety Scientist

At AstraZeneca we work together across global boundaries to make an impact and find answers to challenges! We do this with the upmost integrity even in the most difficult situations because we are committed to doing the right thing. We continuously forge partnerships that help pursue world-class medicines in new ways, combining our people’s exceptional skills with those of people from all over the globe.
The role: As a Discovery Safety Scientist/Specialist, in Respiratory & Immunology (R&I) Safety, within Clinical Pharmacology and Safety Sciences. If you’re looking for a role where you can bring your combination of your experience in biology/toxicology/pharmacology, respiratory/immunology science and drug discovery, this is the role for you!
Respiratory & Immunology (R&I) Safety is a leading respiratory safety organization that develops and integrates innovative safety science with toxicology excellence to drive the design, selection and successful development of novel treatments for patients with respiratory disease.
We are a diverse international department comprised of project toxicologists, discovery safety specialists, respiratory safety professional and experimental scientists. We work collaboratively and develop and apply cutting edge technologies such as tissue organoids, microphysiological systems, multi-omics, state-of-the-art imaging and artificial intelligence, and push the boundaries of predictive safety science with our mission in mind: to discover safe innovative medicines for the patients that need them.
What you'll do:
Contribute to the discovery of innovative treatments for Respiratory & Immunological (R&I) diseases.
Be responsible for the safety strategy and input to multi-disciplinary drug-hunting project teams. You will lead drug safety teams to influence project decision making with the aim to deliver molecules with the “Right Safety” profile.
Develop innovative solutions and research proposals based on strategic needs versus the discovery project portfolio, to pursue cutting edge science and technologies in order to optimize and influence safety assessment of novel drug targets.
Design project-specific in vitro and in vivo strategies to predict, assess and mitigate target- and delivery-related safety risks and execute through internal and external experimental capabilities.
Engage with world-class experts across our organization to develop, refine and implement experimental strategies to ensure that teams make the right decisions regarding safety risks. You will operate across international boundaries within CPSS and across R&D functions in AstraZeneca to lead and manage projects and partners.



Education/Experience Requirements:
PhD in cell biology, toxicology, pharmacology, systems biology or related field, and a strong publication record demonstrating scientific excellence, with 3+ years of proven experience.



Essential Skills/Abilities:
Solid understanding of the drug discovery and development process from the pharmaceutical industry, with an appreciation of fields within and outside safety and toxicology, and preferably a track record of successful contributions to progression of drug discovery projects.
Strong communication, presentation and influencing skills across levels/fields.
Highly motivated, innovative, reliable scientist, with collaborative attitude, who solves problems in a goal-focused fashion.
Knowledge/experience in the respiratory/immunology field will be considered an advantage.
Experience in designing and/or executing safety strategies in drug discovery projects will be considered an advantage.
Experience with design and execution of in vitro and/or in vivo experiments to determine the effects of therapeutics (e.g. monoclonal antibodies, oligonucleotides, peptides, etc) on biological systems.
Experience of working with biologics and knowledge of relevant regulatory guidelines.
A collaborator that contributes to an open, positive, collaborative working

Benefits:
AstraZeneca is a leading company in the healthcare industry, with a mission to enrich the lives of others. It’s our business to support healthy living, not only for our patients, but also for our employees. Our benefits program is flexible enough to meet employees’ varying needs, offers valuable choices, and is highly competitive climate.

Why AstraZeneca?
At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognising their potential. Join us on our journey of building a new kind of organisation to reset expectations of what a bio-pharmaceutical company can be. This means we’re opening new ways to work, pioneering cutting edge methods and bringing unexpected teams together.