Discovery Safety Specialist/Toxicologist to CVRM Safety

Are you a passionate and experienced Discovery Safety Specialist/Toxicologist looking for your next challenge? Would you like to bring your scientific excellence to CVRM Safety and become a key player in the discovery of safe innovative medicines? If yes, this might be the opening for you!

We are now looking to recruit a Discovery Safety Specialist/Toxicologist to strengthen the Safety Science and Discovery team within the Cardiovascular, Renal and Metabolism (CVRM) Safety department. The position will be placed at our vibrant R&D sites in Gothenburg, Sweden.

We continually push the boundaries of science to deliver medicines that treat diseases across our main therapy areas. Through our integration with Alexion, this now includes expanding the limits of scientific research to better understand rare diseases and to discover new life-changing treatments for them.

In this role you will play an important part in the CVRM Safety department, within the larger global Clinical Pharmacology & Safety Science (CPSS) function. The Safety Science and Discovery teams develop and apply innovative scientific strategies to drive the design and selection of safe medicines for patients suffering from Cardiovascular, Renal and Metabolic (CVRM) diseases.

What you will do:
As true Drug Hunting partners to BioPharma R&D, we contribute to the selection of novel drug targets, design of therapeutic concepts, identification and optimization of different modalities, and the selection of novel candidate drugs. We develop and apply cutting edge molecular, cellular and in vivo technologies to push the boundaries of predictive safety science and investigative toxicology.

You will also be responsible for the safety strategy in multi-disciplinary drug discovery project teams and provide scientific leadership to influence project decision making with the aim to deliver molecules with the Right Safety profile. As well as:

* Design and build in vitro and in vivo strategies to predict, assess, and mitigate target- and drug-related safety risks and execute through internal and external experimental capabilities.
* Develop innovative solutions and research proposals based on strategic needs of the discovery project portfolio, and to pursue cutting edge science and technologies in order to optimize and influence safety assessment of novel drugs.
* Engage with world-class experts across our organization to develop, refine and implement innovative experimental strategies and use the data to assess and/or provide mechanistic understanding of safety issues.

Essential in the role:

* PhD or a higher degree in toxicology, cell biology, pharmacology, systems biology or related field, and a strong scientific track record. Relevant on the job experience will also be considered.
* Experience with design of strategies and/or execution of in vitro and/or in vivo experiments to determine the safety and/or efficacy of therapeutics (experience with small molecules, oligonucleotides, AAV and regenerative therapies is preferred, but also antibodies, peptides etc will be considered an advantage).
* Preferably >3 years' experience as safety scientist in the drug discovery phase (from project conception to candidate drug selection).

The successful candidate is a highly motivated, creative and innovative scientist with a flexible, collaborative and team-oriented mindset. You like to solve problems in a goal-focused fashion and you have strong communication and presentation skills. Along with this, you have a social personality and will enjoy to contribute to our open, positive, collaborative working climate.

Why AstraZeneca?
Join the team unlocking the power of what science can do. We are working towards treating, preventing, modifying and even curing some of the world's most complex diseases. Here we have the potential to grow our pipeline and positively impact the lives of billions of patients around the world.

So, what's next! If this sounds like you next challenge - apply today!

We look forward to get to know you better, send in your application as soon as possible but no later than 27th February, 2022.

For more information about the position please contact hiring manager Mikael Persson, Executive Director, Global Head of CVRM Safety, mikael.persson@astrazeneca.com

Additional information:
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
Make a move to Global Gothenburg: https://www.youtube.com/watch?v=c-Iqbb4aw38
About BioPharmaceuticals R&D: https://www.astrazeneca.com/r-d.html