DMPK Design Leader - Early Respiratory & Immunology (R&I)

Do you have expertise in medicinal or physical chemistry or biotransformation? Would you like to apply your expertise in a global company that follow the science and turn ideas into life changing medicines? Then you could be the new colleague we are looking for!

At AstraZeneca Respiratory & Immunology, we're proud to have an outstanding workplace culture that encourages innovation and teamwork. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.

We are now looking for several motivated individuals on different levels in their career to join the team as Drug Metabolism and Pharmacokinetic (DMPK) Design Leader (DDL). If you have less specific experience, you will assist an experienced DDL whilst training for the role.

Drug Metabolism and Pharmacokinetic (DMPK) Design Leader (DDL) is a strategic and scientific role where you, together with Medicinal Chemists and project representatives from other fields, influence chemical drug design to optimize the ADMET (absorption, distribution, metabolism, excretion, toxicity) properties of our future therapeutic drugs within Respiratory Therapeutic area. It is your responsibility that the DMPK project team delivers the overall non-clinical DMPK, including pre-clinical PK, translational pharmacokinetic and pharmacodynamic relationships, biotransformation and bioanalysis to early drug projects from target selection to lead optimization and candidate drug selection. We believe that you have a solid understanding of DMPK and chemistry and that you will be able to provide expert advice and interpretation of complex drug discovery data.



Main Duties and Responsibilities

* Lead DMPK-related activities and the optimisation of compounds by balancing the properties associated with absorption, distribution, clearance, elimination and lung targeting to ensure that DMPK challenges are thoroughly assessed and resolved
* Deliver DMPK input and data to projects within agreed timelines and to the right quality
* Accountable together with Medicinal Chemistry, Bioscience and Safety, for compound design and effective cross-discipline optimization and Design-Make-Test-Analysis (DMTA) cycles in drug discovery
* Apply an understanding of DMPK and physicochemical properties to support/influence compound design, project progression and project strategy
* Responsible for leading, coordinating and engaging with RIA DMPK colleagues in project related activities
* Prepare clear presentations related to the above for internal governance bodies

Requirements

* Formal training or proven experience of working with pharmacokinetics and drug metabolism.
* PhD or equivalent experience in a relevant field (Medicinal, Organic or Physical Chemistry or bio-pharmaceutics/pharmacokinetics)
* Understanding of correlations between physicochemical characteristics and their influence on DMPK properties and subsequent design of new compounds.
* Have (at least) basic PK modelling skills, understanding of disease biology and linking to PKPD understanding
* Experience from drug discovery cross-functional work and compound/project progression is desirable
* Ability to engage and collaborate across boundaries with a problem solving attitude and focus on delivery



Are you ready to make a difference? Send in your application by August 10th the latest, and we'll make it happen together!

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