DMPK Project Leader (DPL), Cardiovascular, Renal and Metabolism

Are you a project leader with broad and comprehensive understanding of discovery and development DMPK including biotransformation, modelling and simulation and DMPK drug design? Would you like to apply your expertise in a company that follow the science to explore and innovate for the benefit of our patients? Join us to be part of the development of future treatments of Cardiovascular, Renal and Metabolic diseases!

At AstraZeneca, we fearlessly break new ground and collaborate with diverse minds. You will be empowered to be innovative and creative where difference is valued. We thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment.

We are now recruiting a DMPK Project Leader to join the DMPK department within Research and Early Development Cardiovascular, Renal and Metabolism (CVRM). The position can be at Associate Director or Director level depending on experience.

CVRM is one of the three main therapeutic research areas within AstraZeneca which deliver candidate drugs into clinical development. CVRM DMPK is based in AstraZeneca's world-class vibrant R&D center, located in Gothenburg, Sweden. DMPK interacts with other functions in supporting CVRM projects along the value chain, from target selection all the way to launch and life cycle management.

The DMPK Project Leader role is both strategic and scientific and as a DMPK Project Leader you occupy a high profile and visible role. The DMPK Project Leaders are responsible for the overall non-clinical DMPK (including pre-clinical PK, translational PK and PK/PD, biotransformation and bioanalysis) contribution to projects from lead optimization through to Life Cycle Management to fulfil both internal and regulatory requirements. You will work with skilled ad hoc core DMPK teams to manage and deliver timely input to the projects you represent.

What you'll do

* Establish and lead the project core DMPK team for the delivery of the non-clinical DMPK package for drug candidates for various drug modalities from Lead Optimization throughout Life Cycle Management
* Define programmes to understand the DMPK and meet internal/regulatory requirements consistent with project milestones and timelines
* Evaluate, interpret and integrate DMPK data to drive project deliverables - including review and transition through internal governance bodies
* Project manage deliverables from internal/external sources and facilitate interpretation/integration into project knowledge
* Work collaboratively with key colleagues in the project core team as well as the DMPK design leader, non-clinical modellers and Clinical Pharmacology scientists and act as the bridge for exchanging knowledge, data and progress
* Initiate and coordinate activities with other AZ functions to drive the understanding of DMPK aspects of drug candidates
* Prepare the DMPK part of regulatory documents (e.g. IND, IMPD, IB, NDA)
* Represent project DMPK information in meetings and communications with authorities as well as in Due Diligence and all in-licensing activities
* Publish scientific papers describing the non-clinical DMPK of their projects

Essential for the role

* PhD or equivalent in relevant discipline, and at least three years of experience relevant to the position
* Broad background and comprehensive understanding of discovery and development DMPK including biotransformation
* Significant experience of leading and managing projects and teams to deliver scientific and functional knowledge from lead optimisation to life cycle management
* Ability to operate across operational, tactical and strategic elements of the business
* Broad experience in pharmaceutical R&D including compiling regulatory submissions
* Track record of delivering DMPK contribution in discovery and development settings
* Good understanding of chemistry, biology, pharmacology, clinical pharmacology, translational medicine
* Highly developed interpersonal, communication (written and oral), organisational and relationship building skills
* Flexibility and ability to thrive in a rapid paced environment
* Capable of making difficult decisions in uncertain/evolving situations
* Proven ability to deliver high-quality solutions on time and within budget in a global environment

This is an exciting opportunity for a talented DMPK scientist with discovery and development experience to join a strong team at the forefront of DMPK science, to support the portfolio of a major pharmaceutical company that has science at its heart and a tremendously strong pipeline whilst being based in the wonderful city of Gothenburg, Sweden.

So, what's next?

Are you already imagining yourself joining our team? Good, because we can't wait to hear from you!

For more information about the position please contact recruiting manager Rasmus Jansson Löfmark, rasmus.jansson.lofmark@astrazeneca.com

Welcome with your application no later than March 31, 2021

Where can I find out more?

Our Gothenburg site: Link

Life in Gothenburg: Link

Culture and atmosphere of the Gothenburg site: Link