DMPK Project Leader within Early Respiratory & Immunology (R&I)

Are you an experienced drug discovery scientist with expertise in pharmacokinetics, pharmacology and drug metabolism (DMPK)? Would you like to apply your expertise in a global company that follows the science and turn ideas into life changing medicines? Then you could be the new colleague we are looking for!

At AstraZeneca Respiratory & Immunology, we are proud to have an outstanding workplace culture that encourages innovation and teamwork. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.

We are now looking for an experienced and motivated individual to join the team as a DMPK Project Leader. The position is placed at AstraZeneca's dynamic R&D site in Gothenburg, Sweden. Working at AstraZeneca means being entrepreneurial, following the science, scrutinizing data and details simultaneously with holistic thinking and through teamwork make progress.

Respiratory & Immunology is one of the three main therapeutic research areas within AstraZeneca. Early R&I is a global function, with research units in Gaithersburg (US), Cambridge (UK) and Gothenburg (Sweden), and delivers candidate drugs into late-stage clinical development. DMPK interacts with other functions in supporting Early R&I projects all along the value chain, from target selection all the way to market launch and Life cycle management.

What you'll do

With a true passion for drug discovery you will support our portfolio within the R&I therapeutic area. In the DMPK lead role you will work collaboratively with discovery project representatives from other disciplines. These may include biology, antibody Discovery/Protein Engineering, medicinal chemistry, safety and pharmaceutical sciences, where your task is to influence drug design by finding out what properties needs to be optimised.

It is your responsibility to ensure delivery of all DMPK related activities. These include preclinical PK experiments, in vitro ADME and biotransformation to yield pharmacokinetic understanding. Furthermore, assisting design of pharmacodynamic studies that ultimately delivers a pharmacological assessment underpinning human dose prediction.

You will work on drug discovery projects from target selection to candidate drug selection. We believe that you have a solid understanding of DMPK, a working knowledge of pharmacology, and that you will be able to provide expert advice and interpretation of complex drug discovery data.

Main Duties and Responsibilities

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Communicate scientific progresses both externally and internally
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Deliver DMPK input and data to projects within agreed timelines and to the right quality
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Accountable together with other disciplines for compound design and effective cross-discipline optimization and Design-Make-Test-Analysis (DMTA) cycles in drug discovery
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Apply an understanding of DMPK to support/influence compound design, project progression and project strategy
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Define and deliver a translational quantitative PKPD strategy in projects, so that effective conclusions can be made
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Contribute to estimation of safety margins and report results and interpretations to project teams and internal governance bodies
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Responsible for leading, coordinating and engaging with R&I DMPK colleagues in project related activities
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Prepare clear presentations related to the above for internal governance bodies



Essential requirements

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Formal training or proven experience of working with pharmacokinetics and preferably drug metabolism.
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PhD or equivalent experience in a relevant field
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Have (at least) basic PK/PD modelling skills and experience of human dose and PK prediction,
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Have (at least) basic pharmacological training and experience
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A proven track record with extensive experience from drug discovery and cross-functional working
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Ability to engage and collaborate across boundaries with a problem solving attitude and focus on delivery



Are you ready to make a difference? Send in your application by 18 April, 2021 and we'll make it happen together!



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