Drug Delivery Scientist - Formulation

At AstraZeneca we turn ideas into life changing medicines and strive to continuously meet the unmet needs of patients worldwide. Working here means being entrepreneurial, thinking big, and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you're our kind of person.

We continually push the boundaries of science to deliver medicines that treat diseases across our main therapy areas. Through our integration with Alexion, this now includes expanding the limits of scientific research to better understand rare diseases and to discover new life-changing treatments for them.

Pharmaceutical Sciences is a department within AstraZeneca Biopharmaceutical R&D. The Pharmaceutical Sciences' mission is to transform molecules into investigational medicines, meeting the unmet needs of future patients. Advanced Drug Delivery is a department in Pharmaceutical Sciences. Our portfolio of projects spans traditional small molecules, proteins, oligonucleotides to RNA based therapeutics across AstraZeneca's therapy areas and our mission is to transform diverse modalities into investigational medicines.

We are now looking for a senior drug delivery scientist with strong expertise in the formulation and analytical sciences to work on delivering new modalities for gene therapy.

The position is based at our vibrant R&D site in Gothenburg, Sweden.



What You'll do

In this role you will be responsible for design and characterisation of formulations for the delivery of nucleic acids. This will involve working with advanced drug delivery platforms such as lipid nanoparticles. Working in close collaboration with peers in the advanced drug delivery group, you will continually be improving our end to end formulation design, characterisation and testing capabilities. As part of the team you will serve on global drug project teams working with scientists across UK, US and Sweden. You will also be expected to be part of and drive science networks and provide high quality scientific input across the organisation.

We expect you to be an active member of the external scientific community enhancing our reputation as scientific leaders in the advanced drug delivery field.

We are seeking an ambitious scientist with a strong foundation in the delivery sciences and a specialisation in the formulation and analytical sciences as well as a great passion for experimental science. This is a hands-on, lab-based position where you will work with different teams, so you should like communicating and have the capacity to share your data.

If you are committed to developing your career in the pharmaceutical sciences - this might be the role for you!



Essential for the role

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Master's degree in pharmaceutical sciences, biology, chemistry or a related discipline
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Experience of formulating colloidal products such as lipid nanoparticles, polymeric delivery vehicles, other nanoparticle technologies
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Strong technical knowledge of nucleic-acid based drug delivery technologies
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Experience in analytical instrumentations used in formulation characterization (particle size and zeta potential measurements, pKa determination etc.)
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Strong record of scientific excellence evidenced by publications, patents and presentations
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Thorough understanding of principles, applications and management of Safety Health and Environment (SHE)



Desirable for the role

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PhD degree in pharmaceutical sciences, chemistry or a related discipline
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Experience working with nanomedicines, especially LNPs
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Practical experience formulating intracellular delivery systems for nucleotides in an industrial setting
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A working knowledge of CRISPR-related biology and a good knowledge of endosomal biology
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Practical skills for the design and synthesis and purification of new materials to support nucleic acid delivery efforts
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Practical skills with cell based and in vivo assays to assess the performance of nanomedicines



Are you ready to make a difference? Send in your application, and we'll make it happen together.

For more information about the position please contact Director Ulrika Tehler, at ulrika.tehler@astrazeneca.com

We encourage you to send your application (CV and cover letter) as soon as possible, but no later than September 22, 2022.



Additional information

Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html

Life in Gothenburg: https://www.movetogothenburg.com/

Culture and atmosphere of the Gothenburg site: https://www.linkedin.com/feed/update/urn:li:activity:6496327311678410752/