Drug Metabolism & Pharmacokinetic Design Leader Early R&I

Are you an experienced DMPK scientist with expertise in drug discovery? Would you like to apply your expertise in a global company that truly follows the science and turn ideas into life changing medicines? Then you could be the new colleague we are looking for!

At AstraZeneca Respiratory & Immunology, we're proud to have an outstanding workplace culture that encourages innovation and teamwork. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.

We are now looking for an experienced and motivated individual to join the team as a DMPK Design Leader (DDL).

In the DDL role you would work collaboratively with discovery project representatives from other disciplines including medicinal chemistry, biology, safety and pharmaceutical sciences, to influence drug design and optimization of ADMET (absorption, distribution, metabolism, excretion, toxicity) properties. It is your responsibility to ensure delivery of DMPK related activities , including in vitro ADME, preclinical PK, translational pharmacokinetic and pharmacodynamic relationships underpinning human dose prediction biotransformation and bioanalysis to early drug projects from target selection to candidate drug selection. We believe that you have a solid understanding of DMPK and chemistry and that you will be able to provide expert advice and interpretation of complex drug discovery data.

Main Duties and Responsibilities

* Lead DMPK-related activities and the optimisation of compounds by balancing the properties associated with absorption, distribution, clearance elimination to ensure that DMPK challenges are thoroughly assessed and resolved
* Deliver DMPK input and data to projects within agreed timelines and to the right quality
* Accountable together with Medicinal Chemistry, Bioscience and Safety, for compound design and effective cross-discipline optimization and Design-Make-Test-Analysis (DMTA) cycles in drug discovery
* Apply an understanding of DMPK and physicochemical properties to support/influence compound design, project progression and project strategy
* Responsible for leading, coordinating and engaging with R&I DMPK colleagues in project related activities
* Prepare clear presentations related to the above for internal governance bodies

Requirements

* Formal training or proven experience of working with pharmacokinetics and drug metabolism.
* PhD or equivalent experience in a relevant field
* Understanding of correlations between physicochemical characteristics and their influence on DMPK properties and subsequent design of new compounds.
* Have (at least) basic PK modelling skills, experience of human dose and PK prediction, understanding of disease biology and linking to PKPD understanding
* Experience from drug discovery, cross-functional working and compound/project progression is desirable
* Ability to engage and collaborate across boundaries with a problem solving attitude and focus on delivery



Are you ready to make a difference? Send in your application by December 13th the latest, and we'll make it happen together!

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