ERC-funded Postdoctoral Researcher in single-cell immunology

Do you want to contribute to top quality medical research?
We are looking for an ambitious postdoc with solid single-cell immunology skills to join our highly accomplished team of immunologists in a project (GUT-SEQ) funded by the European Research Council (ERC).

We offer a stimulating environment in a rapidly moving research frontier.

Your mission
The Mjösberg group (https://mjosberglab.wixsite.com/ilcs and https://ki.se/en/medh/jenny-mjosberg-group) studies the development, regulation and function of innate lymphoid cells (ILCs), in humans, and how these cells contribute to pathology in mucosal organs such as the lung and gut. The studies are translational as they involve advanced basic molecular and cellular immunological investigations of precious human tissue samples to discover novel disease mechanisms and therapy targets. The group is internationally recognized as a leader in the field through several high impact publications in recent years (Nat Immunol 2016, Nat Comm 2020, Cell Res 2020 etc).

The postdoc will continue the successful line of investigations utilizing single-cell RNA sequencing (scRNA-seq) to dissect human intestinal mucosal ILC and T cell biology in health and disease. The successful candidate will be part of a team in an ongoing project that involves dissection of gut-associate lymphoid tissues from human intestinal specimens and generation of scRNA-seq (SMARTseq and 10X genomics) data as well as multicolor flow cytometry data of human mucosal ILCs and T cells from these tissues. The data will be analyzed in close collaboration with bioinformaticians at SciLifeLab. As this is a team effort, excellent communication skills are essential, as is proven ability to work in multidisciplinary teams. It is expected that the postdoc also supervises students and other researchers if necessary, as well as contribute to common lab duties.

Your profile
Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant's main supervisor, director or equivalent.

The candidate must hold a PhD equivalent to a Swedish doctoral degree in the field of immunology. The candidate must fully master multidimensional (>20 parameters) flow cytometry analysis and sorting, as well as be experienced in scRNAseq. Experience in isolation and in vitro culturing of primary immune cells is a requirement, as is basic functional in vitro assessments of immune cell function such as intracellular cytokine stainings, ELISA etc. The candidate should be familiar with R software and have some experience analyzing scRNAseq data. The candidate should have a strong publication track-record. The candidate should be self-motivated, have good communications skills and a proven ability to interact effectively and work productively in an interdiciplinary team. Fluency in English is a requirement as well as some basic skills and willingness to learn Swedish.

What do we offer?
A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote better health for all. At Karolinska Institutet, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. Karolinska Institutet is a state university, which entitles employees to several benefits such as extended holiday and a generous occupational pension. Employees also have free access to our modern gym and receive reimbursements for medical care.


Location: Flemingsberg


Read more about the Center for Infectious Medicine https://ki.se/en/medh/center-for-infectious-medicine,
and more about the project you will be working on https://cordis.europa.eu/project/id/850963.



Application
An employment application must contain the following documents in English or Swedish:

- A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
- A complete list of publications
- A summary of current work (no more than one page)
- A personal letter explaining the interest in the position
- Contact details for two referees

Welcome to apply at the latest 2021-01-31

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all