Experienced Scientist - Stem Cell Biology & Lung development

Are you an experienced scientist in the field of stem cells and lung development? Would you like to use this expertise to contribute to the development of novel therapies? If yes, we might have the right opening for you!

At AstraZeneca in Gothenburg, Sweden we have an exciting opportunity for a motivated scientist who will work as a Senior Scientist/Associate Principal Scientist in the Applied Stem Cell Sciences group in Translational Genomics, Discovery Sciences, Biopharmaceuticals R&D. As a bench-based experienced scientist you will be a key player in developing therapeutics to change patients' lives.

Translational Genomics belongs to the wider Discovery Biology department with a common goal to innovate at the interface of science and technology. Our mission is to discover new targets, to create reagents, assays and disease models to discover new medicines, and to develop cell and gene therapies.

What you'll do:
Using your strong knowledge and experience in stem cell biology, cell model development and CRISPR technology you will have the opportunity to develop novel stem-cell derived respiratory disease models. This includes culture, genome-engineering and differentiation of induced pluripotent stem cells (iPSCs) and genetic and functional validation of engineered lines. You will be working alongside our stem cell scientists, disease area specialists and genome editing group.

The role is focused on laboratory-based activities and your biggest impact will be through significant contributions to the practical delivery to projects in compliance with AstraZeneca corporate responsibility, policies and relevant safety standards. You will get the opportunity to mentor research associates. Other accountabilities:

* Culture and differentiation of human iPSC lines to lung cell types and organoids.
* Design and implementation of iPSC genome engineering projects to advance functional studies in disease relevant cell types.
* Perform molecular biology, biochemical, and cellular assays to evaluate the outcomes of gene editing experiments on genomic DNA, mRNA, protein, and functional levels.
* Design, develop, and optimize in vitro transfection/transduction experiments using a variety of perturbagens, including lentivirus/AAV-mediated infection.

Essential in the role:

* PhD in Developmental Biology, Cell Biology, or equivalent with +5 years of academia or industry experience.
* Demonstrable scientific impact and innovation capacity through publication record.
* Proven experience with PSC biology and carrying out functional assays with iPSC-derived cell types.
* Experience with scRNAseq applications in cell lineage analysis.
* Demonstrable experience with cell line engineering using CRISPR/CAS9.
* Proficiency with the following assay platforms: RT-qPCR, ddPCR, Flow Cytometry, ELISA, Western blots, and cellular functional assays.
* Experience with the culture of multiple mammalian cell types including primary cells.

It is also essential to have the ability to communicate, collaborate and be a strong team player in multidisciplinary team. This should go hand in hand with you skills to work independently, take own initiatives and have a positive, goal oriented and problem-solving attitude. Depending on your previous experience we will tailor the level of the role to suit you the best.

Desirable in the role:

* Experience with NGS library prep, bioinformatic analysis, and cutting-edge molecular biology methods.
* Expertise with liquid handling automation technologies.
* Experience of setting up cell based pharmacological assays.

Why AstraZeneca?
Join the team unlocking the power of what science can do. We are working towards treating, preventing, modifying and even curing some of the world's most complex diseases. Here we have the potential to grow our pipeline and positively impact the lives of billions of patients around the world.

So, what's next? If this sounds like your next career step - apply today!

We look forward to get to know you better, so submit your application as soon as possible but no later than 6th March, 2022.

For more information about the position please contact Hiring Manager, Bilada Bilican at bilada.bilican(at)astrazeneca.com.

Additional information:
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Relocating to Gothenburg: https://www.astrazeneca.se/om-oss/verksamheten-i-sverige/goteborg/relocate-to-gothenburg.html
About BioPharmaceuticals R&D: https://www.astrazeneca.com/r-d.html