Functional Genomics /Molecular Biomarker Scientist

Are you a driven Functional Genomics specialist and Molecular Biomarker Scientist ready for your next challenge within the field? Would you like to apply your expertise to impact the discovery and validation of novel genetic biomarkers in respiratory and immunology therapeutic areas in a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the one for you!

At AstraZeneca, we believe in the potential of our people no matter where you start with us. By developing your skills and passion, we encourage you to perform at your very best. We strive to make a difference for patients around the world every day, and we hope that you want to join us on our journey.



Job Description

Respiratory and Immunology are two of AstraZeneca's main therapy areas. Our Early R&I Translational Science and Experimental Medicine (TSEM) department is an agile environment with a strong science focus. Our mission is to understand disease mechanisms at the molecular level, identify the most effective target and the right patient population. In order to close the gap between bench science and bedside clinical practice. These efforts include a focus on establishing correlations with genetic biomarkers and comprehensive clinical assessments of disease activity, with multiple cohorts being comprehensively profiled to enable these efforts.

One of our key remits is the development of biomarkers to drive patient segmentation, demonstrate target engagement, guide dose selection and bridge to clinical outcome. As a Functional Genomics /Molecular Biomarker Scientist, you have significant experience in the invention and discovery of novel biomarkers. You are accountable for discovery and functional validation of respiratory and inflammation precision medicine genetic and molecular biomarkers, as well as their further development as clinically meaningful measures. You will be recognized as a specialist in molecular biomarkers, seen as point of reference for others, and drive innovation in the Biomarker Discovery team through internal scientific development and external collaborations. You will raise AZ scientific visibility through publishing scientific papers and presenting data at conferences.



The role will entail and require experience and understanding in the following areas:

* You have significant experience in the invention and discovery of novel biomarkers
* Experience from investigation of the relationships of SNPs with molecular and clinical phenotype
* A broad understanding of opportunities and limitations of NGS (next-generation sequencing) technologies in the context of biomarker discovery
* Experience and understanding of DNA and RNA manipulation for biomarker discovery
* Experience in establishing novel molecular biology techniques to identify biomarkers
* Experience in the investigation and determination of causality of genetic variants
* Responsibility for design, execution, interpretation and reporting of molecular based biomarker studies
* Validate knowledge extracted from big Omics-datasets through considered and robust biomarker analysis of human tissue
* Use of clinical tissue to identify and validate biomarkers

Essential Requirements

This is a role that requires a strong scientific background as well as excellent technical skills. You are familiar with biomarker invention and implementation and you have a strong publication record. We believe that you have outstanding team working and networking skills and a history of successful collaborations. Furthermore, you have in dept understanding of the drug discovery and development process from lead identification through clinical trials.

* PhD or equivalent within relevant field.
* Experience in design, execution and interpretation of functional genomic assays for determination of causality of variants
* Track record of delivering state-of-the-art biomarkers to projects in discovery and/or development setting.
* Proven experimental drive and background in basic science related to respiratory research.
* Technical expertise in specific biomarker discovery and analysis platforms including but not limited to - genomics, transcriptomics, epigenomics, NGS, etc.
* Detailed experience and knowledge of the biological basis for patient segmentation and precision medicine
* Understanding of relevant technologies and methods along with scientific laboratory skills.

Desirable Requirements

* Post-doc experience in a relevant field
* Experience in pharmaceutical R&D
* Experience and deep understanding of respiratory and or inflammation disease biology, including understanding of molecular pathways and mechanisms.



If you are interested, apply now!

Welcome with your application no later than February 21st, 2021

For more information about the position please contact Zach Brohawn, zach.brohawn@astrazeneca.com



Where can I find out more?

Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html

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