Molecular Biomarker Scientist

Are you a hardworking Scientist ready for your next challenge within the field? Would you like to apply your expertise to impact the discovery of new inflammation precision and target engagement biomarkers in a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the one for you!

At AstraZeneca, we believe in the potential of our people no matter where you start with us. By developing your skills and passion we encourage you to perform at your very best. We strive to make a difference for patients around the world every day, and we hope that you want to join us on our journey.



Job Description

Respiratory and Immunology is two of AstraZeneca's main therapy areas. Our Early R&I Translational Science and Experimental Medicine (TSEM) department is a nimble environment with a science focused atmosphere. Our mission is to understand disease mechanisms at the molecular level, identify the most effective target and the right patient population. In order to close the gap between bench science and bedside clinical practice.

One of our key remits is the development of biomarkers to drive patient segmentation, demonstrate target engagement, guide dose selection and bridge to clinical outcome. As a molecular Biomarker Scientist, you are accountable for discovery of respiratory and inflammation precision and target engagement biomarkers and their development and validation. You will be recognised as a specialist in molecular biomarkers, seen as point of reference for others. Drive innovation in Biomarker Discovery through internal scientific development and external collaborations. You will raise AZ scientific visibility through publishing scientific papers and presenting data at conferences.

You will have experience and understanding in the following areas:

* You have a detailed experience from invention and discovery of novel biomarkers
* Investigating the regulation of gene expression in a disease setting, either at the gene, transcript or epigenetic level
* A broad understanding of opportunities and limitations of NGS (next-generation sequencing) technologies in the context of biomarker discovery
* Experience and understanding of DNA and RNA manipulation for biomarker discovery
* Experience in establishing novel molecular biology techniques to identify biomarkers
* Experience in the development of liquid biopsy techniques to identify and measure novel biomarkers
* Responsibility for design, execution, interpretation and reporting of molecular based biomarker studies
* Validate knowledge extracted from big omics-datasets through robust biomarker analysis in human tissue
* Use of clinical tissue to identify and validate biomarkers



Essential Requirements

This is a role that requires a strong scientific background as well as excellent technical skills. We believe that you have outstanding team working skills and a history of successful collaborations. Furthermore, you have in dept understanding of the drug discovery and development process from lead identification through clinical trials.

* PhD or equivalent within relevant field.
* Track record of delivering state-of-the-art biomarkers to projects in discovery and/or development setting.
* Familiar with biomarker invention and implementation.
* Proven experimental drive and background in basic science related to respiratory research.
* Technical expertise in specific biomarker discovery and analysis platforms including but not limited to - genomics, transcriptomics, epigenomics, NGS, etc.
* Detailed experience and knowledge of the biological basis for patient segmentation and precision medicine
* Good networking and interpersonal skills
* Strong publication record
* Understanding of relevant technologies and methods along with scientific laboratory skills.

Desirable Requirements

* Post-doc experience in a relevant field
* Experience in pharmaceutical R&D
* Experience and deep understanding of respiratory and or inflammation disease biology, including understanding of molecular pathways and mechanisms.



Welcome with your application no later than June 2nd, 2020.

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