Molecular Biomarker Scientist

Are you a driven Molecular Biomarker Scientist ready for your next challenge within the field? Would you like to apply your scientific expertise in respiratory and immunology therapeutic areas in a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the one for you!

At AstraZeneca, we believe in the potential of our people no matter where you start with us. By developing your skills and passion, we encourage you to perform at your very best. We strive to make a difference for patients around the world every day, and we hope that you want to join us on our journey.

What you'll do

Respiratory and Immunology are two of AstraZeneca's main therapy areas. Our Early R&I Translational Science and Experimental Medicine (TSEM) department is an agile environment with a strong science focus. Our mission is to understand disease mechanisms at the molecular level, identify the most effective target and the right patient population. In order to close the gap between bench science and bedside clinical practice.

One of our key remits is the development of biomarkers to drive patient segmentation, demonstrate target engagement, guide dose selection and bridge to clinical outcome. As a molecular Biomarker Scientist you are accountable for discovery of respiratory and inflammation precision and target engagement biomarkers and their development and validation specifically, but not limited to, the fields of transcriptomics and proteomics.

The role will entail and require experience and understanding in the following areas:

* Broad understanding of opportunities and limitations of NGS (next-generation sequencing technologies) in the context of biomarker discovery
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Experience in NGS techniques
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Experience and understanding of manipulation of DNA and RNA to create custom assays fit for biomarker discovery
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Experience in setting up novel molecular biology techniques
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Be responsible for design, execution, interpretation and reporting of molecular based biomarker studies
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Be providing and serve as an expert in the development and deployment of novel molecular based biomarker platform technologies to enable the respiratory biomarker discovery platform
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Invent and discover novel biomarkers through bioinformatic analysis of omics datasets
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Dedicatedly exploit available omics-initiatives
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Validate knowledge extracted from big omics-datasets through robust biomarker analysis in human tissue
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Use experimental medicine (MeMo studies) to identify and validate biomarkers and support recall by genotype clinical study designs
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Drive innovation in Biomarker Discovery through internal scientific development and external collaborations
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Make AZ scientifically visible by publishing scientific papers and presenting data at conferences

Essential for the role

This is a role that requires a strong scientific background as well as excellent technical skills. You need outstanding team working skills and a history of successful collaborations. Furthermore, you are expected to have a deep understanding of the drug discovery and development process from lead identification through clinical trials.

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PhD within relevant field.
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Experience in design, execution and interpretation of functional genomic assays for determination of causality of variants
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Track record of delivering state-of-the-art biomarkers to projects in discovery and/or development setting
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Proven experimental drive and background in basic science related to respiratory research
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Familiar with biomarker invention and implementation.
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Experience and knowledge of the biological basis for patient segmentation and precision medicine
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Strong publication record
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Understanding of relevant technologies and methods along with scientific laboratory skills



Desirable for the role

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Post-doc experience in a relevant field
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Experience in pharmaceutical R&D
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Experience and deep understanding of respiratory and or inflammation disease biology, including understanding of molecular pathways and mechanisms.

So, what's next!

Are you already imagining yourself joining our team? Good, because we can't wait to hear from you.

Welcome with your application no later than 19 February, 2021

Where can I find out more?



Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html

Life in Gothenburg: https://www.movetogothenburg.com/

Culture and atmosphere of the Gothenburg site: https://www.linkedin.com/feed/update/urn:li:activity:6496327311678410752/