Postdoc Fellow A cell biological, mechanistic exploration

Of how membrane fluidity (MF) can affect nanoparticle (NP) processing and performance and how nanomedicines might be optimised accordingly
AstraZeneca is a global, science-led, patient-centred biopharmaceutical company that focuses on discovering, developing, and commercialising prescription medicines for some of the world's most serious diseases. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we're dedicated to being a Great Place to Work, where you are empowered to push the boundaries of science and fuel your entrepreneurial spirit. There's no better place to make a difference to medicine, patients and society.
About the Postdoc Programme
Bring your expertise, apply your knowledge, follow the science and make a difference!
AstraZeneca's Postdoc Programme is for self-motivated individuals looking to tackle exciting, high impact projects in a collaborative and innovative environment.
Working with peers and professionals from a diverse set of backgrounds, together with an elite academic mentor explicitly aligned to your project, you'll be respected as a specialist and encouraged to speak up. You'll lead a novel and innovative research project at the interface of drug discovery and biopharmaceutical development in a multidisciplinary scientific environment. You'll be empowered and supported to drive the success of your project, publish papers, achieve your goals and make a difference to our patients.
Running alongside your research project, our postdoc training program will help you learn about drug discovery and development from industry leaders working in our innovative research laboratories and organisation.
About the Opportunity
Our postdoc program is well-established and full of dedicated scientists that form an active and very collaborative community. From AstraZeneca's largest R&D site in Gothenburg, you will gain direct experience in the pharmaceutical industry and pursue your research in pioneering laboratories.
We would like you to do experimental science, make discoveries, and have fun doing it. You will have the support of a leading academic advisor, Professor Marc Pilon, with deep knowledge of membrane fluidity, who'll help provide you with the mentorship and expertise you need to develop your career. As well as Dr. Alan Sabirsh, Principal Scientist, Advanced Drug Delivery at AstraZeneca, who knows the lab systems well and has extensive experience working with successful postdoc projects. You will be joining a team that has benefitted from a series of postdoc projects. Much of the infrastructure is well-established, and many of our previous postdocs can collaborate, as they are now permanent employees. We have tried to reduce the risk associated with the project by generating preliminary data and designing the project to align with previous or ongoing work.
This is an exciting area that hasn't been explored to its full potential. Yet, it is also a very hot topic within the biotech sector, making this a chance to create a real difference to the future of medical science and your career!
Qualification, Skills & Experience
Required:
PhD degree with a specialisation in cell biology, biotechnology or, equivalent scientific field
Extensive experience with in-vitro cell culture and cell biological methods
Experience with molecular biological methods and genetic manipulation
Good knowledge of endocytosis, intracellular trafficking pathways and relevant intracellular signalling
Experience with advanced microscopy, laboratory automation, high-content biology (robotic microscopy and image analysis; Columbus, MatLab, ImageJ and/or Cell Profiler), gene editing technologies and transcriptomic methods are attractive skills. Candidates will have a high technical competence and demonstrate experience in most or all of these areas
Proven track record to drive innovative research through internalisation of new techniques and technology and forming internal and external collaborations
Track record of scientific excellence, with a strong publication record and engagement with the scientific community through conferences and collaborations. An ability to independently build finished manuscripts will be vital
Desirable:
Experience with robust assay development, including multivariate data analysis, processing and visualisation and, statistical tools for factorial experimental design
Experience with drug delivery technologies for the intracellular delivery of macromolecules, such as lipid nanoparticles
The project will potentially involve disease models of Huntington's disease, cancer and diabetes/obesity, so experience in these areas is desirable
Excellent communication skills in English (written and spoken)
Supervisory skills and experience (for opportunities involving students and more junior personnel)
Are you already imagining yourself joining our team? Good, because we can't wait to hear from you.
This is a 3-year programme. 2 years will be a Fixed Term Contract, with a 1-year extension which will be merit-based.