Postdoc Fellow - Development of DNA repair inhibitors

Imagine… one day we live in a world, where a diagnosis of a severe genetic disease does not sound terrifying, because almost all genetic diseases have effective medicines to cure them. Here at AstraZeneca, we are developing state-of-the-art tools and models to advance gene and cell therapy approaches. Do you want to be part of this effort?

We're currently looking for a motivated scientist to join our innovative PostDoc Programme. The position is placed at AstraZeneca's dynamic R&D site in Gothenburg, Sweden, where you will be in a global pharmaceutical environment, contributing to live projects right from the beginning.

About the Postdoc Programme:
You'll take part in a training programme, including a focus on drug discovery and development, given access to our existing Postdoctoral research, and encouraged to pursue your own independent research in groundbreaking laboratories. It's a newly expanding programme spanning a range of therapeutic areas across a wide range of fields.

What's more, you'll have the support of leading academic advisors, who'll provide you with the guidance and knowledge you need to develop your career. This is an exciting area that hasn't been explored to its full potential, making this a chance to create a real difference to the future of medical science.

About the PostDoc role:
As a postdoctoral scientist in the Genome engineering department, you will join an innovative group of robust individuals who are dedicated to science. We focus on pre-clinical research - understanding fundamental biological processes to eventually craft novel therapeutical approaches and strategies of critical value in various disease areas.

You will own an independent project focused on testing and developing novel DNA repair inhibitors to promote genome engineering of Hematopoietic Stem cells. The project will take advantage of modern equipment and proprietary technologies. You will be encouraged to collaborate with top academic laboratories. We will make sure that you have all the resources required to optimally finalized your project and publish your results. Our work led by former postdoctoral scientists was published in leading journals and is highly cited.

Essential in the role:

* PhD degree in molecular/cell biology/genetics.
* Broad multidisciplinary experience and meticulous scientific knowledge (including strong molecular biology skills and advanced understanding of genetic engineering and hands on working on CRISPR-Cas9).
* Strong understanding of Double Strand Break repair pathways and drug modulation of DSB repair.
* Outstanding work ethic (patience, discipline, the desire to work hard, perseverance and the ability to develop and follow a plan).
* A history of previous competitive success.


We also believe that our successful candidate is a creative, innovative, pro-active, forward-thinking, focused, goal-oriented person. As well as a team player who demonstrates a passion for science with an adventurous, growth mentality.

Desirable in the role:

* Proven experience in HSC gene manipulation.
* Expertise with NGS analysis and phenotyping tools (i.e. FACS) to validate genetic perturbations.

Why AstraZeneca?
AstraZeneca is proud to provide a unique workplace culture that inspires innovation and cross-boundary collaboration. Within this environment employees are empowered to express diverse perspectives, and are made to feel valued, energized and rewarded for their ideas and creativity. Thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment.

So, what's next? If you're curious to know more then please reach out to Marcello Maresca marcello.maresca@astrazeneca.com.

We welcome your application no later than 31 August, 2022.

Additional information:
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
Make a move to Global Gothenburg: https://www.youtube.com/watch?v=c-Iqbb4aw38
About BioPharmaceuticals R&D: https://www.astrazeneca.com/r-d.html

NOTE - Due to our summer vacation period in Sweden during July-August, the screening process may take a bit longer than usual. Thanks for your understanding and we will get back to you as soon as possible when we are back at work.