PostDoc Fellow - In oligo protein cell interactions

Do you have an extensive passion for science and is curious about revealing new insights? Would you like to apply your expertise in cell biology and imaging to develop innovative oligonucleotide therapeutics and make an impact on drug discovery sciences? Then this PostDoc position at AstraZeneca in Gothenburg might be the one for you!

We are looking for a talented and motivated Cell biologist to join our Mechanistic Biology and Profiling Team within the Discovery Sciences department at AstraZeneca in Gothenburg, Sweden as a PostDoc. In a collaborative environment, you will get the opportunity to apply your expertise in cell biology and imaging to contribute and play a meaningful role in advancing the oligonucleotide therapeutic field. This is a temporary position of 2 years, with possibility of extending 1 year.

Our Mechanistic Biology and Profiling Team focuses on improving the mechanistic understanding and efficacy of our oligonucleotide therapeutics. The team operates in a cross disciplinary environment in close collaboration with expert scientists across AstraZeneca R&D units and external collaborators and offers a highly rewarding scientific environment along with an inclusive, dynamic and team focused atmosphere.

Join us and thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment.

What you will do:
You will drive research with the focus on increasing the mechanistic understanding of intracellular oligo:protein interactions to improve the uptake and trafficking of oligonucleotides with the aim to create better oligonucleotide therapeutics. Your main research project will focus on developing and using different techniques to characterize oligo:protein interactions in cells, and correlate results with oligo sequence motifs and chemistries, target modulation efficacy and subcellular localization.

As an expert in cell biology and imaging, you will apply your expertise in proposing experimental strategies, implementing them and troubleshooting challenges to succeed in your role. You will work in close collaboration with a cross-functional team to study the impact of oligo:protein interactions. The strong network of professionals within the AZ oligo community will help to ensure a high impact publication track record. Therefore, the position offers the ability to maintain a competitive research output.

Essential in the role:

* PhD in Cellular or Molecular biology or similar.
* Significant experience working with cells and establishing cell based imaging assays, e.g. immunofluorescence, NanoBret.
* Proven record of applying fluorescence microscopy and image analysis.

Desirable in the role:

* Experience in the area of oligonucleotide therapeutics including studying oligo uptake and intracellular trafficking.
* Experience in studying oligo:protein or protein:protein interactions in cells.
* Scientific excellence as shown by previous work, publication list or references from scientific mentors.

Our successful candidate have a great passion for driving scientific questions, can work independently and have a result oriented, problem-solving and positive attitude. Excellent English is required, both spoken and written, and ability to operate effectively in a multi-disciplinary research environment. We also believe that you enjoy teamwork, have a collaborative nature and be an encouraging colleague to all!

Why AstraZeneca?
Be part of a dedicated Research & Development team. Fuelled by our commitment to help more patients, strengthen our pipeline and grow our area. Here all doors are open, and every voice is heard. From working side-by-side with academia to innovating with biotech - we are forever expanding our horizons. To read more about our AstraZeneca site in Gothenburg, see the additional information below.

What's next? We look forward to finding out more about you. Welcome to send in your application as soon as possible but no later than 31st May, 2021.

More information:
For more information about the position please contact Karl-Johan Leuchowius, Associate Principal Scientist, Mechanistic Biology and Profiling at karl-johan.leuchowius@astrazeneca.com

Additional information:
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
About BioPharmaceuticals R&D: https://www.astrazeneca.com/r-d.html