Postdoc: Patient stratification, AI-guided precision diagnosis

Gothenburg, Sweden

Competitive Salary, Bonus & Benefits

Do you have a passion for or experience in translating patient data patterns into precision medicine and biomarker strategies? Would you like to apply your expertise to impact the kidney disease field in a company that follows the science and turns ideas into medicines? Then this postdoc position at AstraZeneca might be the one for you!

About AstraZeneca:

AstraZeneca is a global, science-led, patient-centred biopharmaceutical company focusing on discovering, developing, and commercialising prescription medicines for some of the world's most serious diseases. But we're more than a global leading pharmaceutical company. At AstraZeneca, we're dedicated to being a Great Place to Work and empowering employees to push the boundaries of science and fuel their entrepreneurial spirit. There's no better place to make a difference in medicine, patients, and society.

About the Postdoc Programme:

Bring your expertise, apply your knowledge, follow the science, and make a difference. AstraZeneca's Postdoc Programme is for self-motivated individuals looking to deliver exciting projects in an encouraging, engaging, and innovative environment. You'll work with multidisciplinary scientific teams from a diverse set of backgrounds and a world-class academic mentor specifically aligned to your project. Our postdocs are respected as specialists, encouraged to speak up, and supported to share their research at conferences, publish papers, achieve their goals and make a difference to our patients.

This is a 3-year programme, with an initial 2-year period and a 1-year merit-based extension.

About the Opportunity:

Early Cardiovascular, Renal and Metabolism (CVRM) are accountable for the discovery and development (up to phase II) of new medicines within three main strategic areas - cardiovascular/heart failure, metabolism (diabetes and NASH) and chronic kidney disease. In addition, the Translational Sciences and Experimental Medicine Department within Early CVRM has the remit to bridge early and late drug development by providing human target identification and validation, biomarker strategy, and precision medicine strategies.

We now have a Postdoctoral Fellow opportunity in the Experimental Medicine team, who delivers exploratory studies in humans, ex vivo and in vitro experiments on human biological samples, and human omics data-driven novel drug target identification.

We are looking for a Postdoc who´s main focus will be on integrative analyses of genomics, kidney histopathology, circulating and urinary proteomics biomarkers, and clinical parameters from a kidney disease cohort, to identify and characterize novel patient subgroups through unbiased stratification.

As part of the postdoctoral programme, you will lead the scientific project with the support of Anna Reznichenko, Senior Director Experimental Medicine at AstraZeneca, and academic guidance and mentorship by Matthias Kretzler, Professor of Internal Medicine-Nephrology and Computational Medicine and Bioinformatics at University of Michigan.

Qualification, Skills & Experience:

Essential Requirements

* PhD in Data Science, Epidemiology, Bioinformatics, Statistical Genetics, Computational Biology, or a related field
* Proven biological knowledge and understanding of human disease pathophysiology, preferably in the kidney disease area
* Hands-on experience working with human data such as omics, biomarkers, clinical data, electronic health records, real-world evidence, imaging, and digital pathology
* Extensive knowledge and experience in big data analysis, biostatistics, machine learning, supervised and unsupervised classification/clustering approaches, integration of various data types, R or Python coding
* Strong peer-reviewed publications and conference presentations track record

Desirable Requirements

* Understanding of patient stratification and precision medicine principles
* Working knowledge of disease biomarkers
* Innovative thinking and creativity - staying up to date with the scientific field, coming up with ideas & generating hypotheses
* Excellent communication and networking skills, with the ability to interact effectively with specialists

Why Should You Apply?

This exciting project presents unique opportunities to generate innovative science, advance the field, and gain hands-on skills and experience applying ground-breaking, exciting analytical approaches to address global biomedical problems.

Our Gothenburg site is one of AstraZeneca's three strategic R&D centres. Here, you'll feel a global atmosphere in a multinational environment. Collaboration comes in all forms - across teams, functions, countries and even companies.

Ready for an exciting, rewarding challenge? Apply today!



Advert Opens: 3rd of October 2022

Advert Closes: 7th of November 2022



Where can I find out more?

Our Gothenburg site: https://careers.astrazeneca.com/sweden

AstraZeneca's Postdoc Programme: https://careers.astrazeneca.com/postdocs-astrazeneca

Life at AstraZeneca: https://careers.astrazeneca.com/life-at-astrazeneca