PostDoc Positions - Precise Genome Editing (PGE)

At AstraZeneca, innovation is more than just research. As one of the world's leading pharmaceutical companies, we?re focused on providing medicines that make a real difference in patient care. That?s why we've invested in a new research centre and corporate headquarters at the Cambridge Biomedical Campus (UK), and in our state-of-the art research facility at Gothenberg, Sweden.

Our research centres are a place where you can help us continue to lead the industry in research and development. A place with an entrepreneurial and collaborative culture, where you'll feel valued, energised and rewarded for your ideas and contributions. A place where talented people can immerse themselves in their work and make significant contributions towards scientific excellence.

We are seeking POSTDOCTORAL FELLOWS at our Cambridge/UK and Gothenberg/Sweden sites to work in the novel and exciting field of precise genome editing (PGE). The successful applicants will be embedded in the Discovery Sciences Department and will join a vibrant community of PostDoctoral Fellows that is already established on both sites in our PGE teams.

Our aim is to develop new tools for the identification and validation of novel drug targets and to contribute to the development of novel therapeutic strategies. The successful candidates will join our PGE global teams and have the opportunity to work and interact with our global AZ PGE community and a significant number of high profile external collaborators (Sanger Institute, Harvard, MIT, UC Berkeley, UCSF, University of Munich, others). These three year positions will provide opportunities for publication, patent applications and conference presentations. We are looking for applicants with enthusiasm, a passion for science, good attention to detail and a desire to create new medicines for patients.

Education:
- PhD degree, preferably in molecular biology, genomics or/and mammalian genetics.
Required:
- Scientific excellence as shown by previous work, publication list and references from scientific mentors.
- Very good understanding of human genetics/genomics and tools used to identify disease-associated genetic variation.
- Extensive hands-on experience with functional genomic tools, preferably including CRISPR/Cas9 genome editing, using in-vitro model systems and/or Extensive hands-on in the generation of animal models particularly using viral or non-viral delivery systems for in-vivo applications of precise genome editing.
- Experience in cell-based assays using a variety of technologies for measuring disease-relevant phenotypes.
- Molecular cloning and gene expression analysis in human cellular systems
- Strong communication and collaborative skills, especially the ability to communicate essential details of experimental design and data to others in a clear and concise manner.
- Ability to be highly collaborative and work as part of both a large multidisciplinary team. The ability to work with both internal and with external partners in both academia and industry.

- Experience with high-throughput methods for........

To read FULL JOBDESCRIPTION and to APPLY, please visit www.astrazeneca.se