PostdocFellow: LINE-1 retroelements being a potential driver

Postdoc Fellow: Unraveling the biology of LINE-1 retroelements and their potential role as drivers in COPD

Location: Gothenburg, Sweden

Innovate to change the world!

Do you have expertise in biocatalysis and a passion for innovation? Would you like to apply your expertise to impact sustainable drug discovery in a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the one for you!



AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development, and commercialisation of prescription medicines for some of the world's most serious diseases. But we're more than one of the world's leading pharmaceutical companies. A place for bold disruptors shifting from academia to industry, this is where you can think differently to cut through the noise, add value, and bring fresh thinking to our teams and projects. Collaborating across functions and international boarders, you'll share knowledge and combine strengths to take your skills, and our science, to the next level.

About the Postdoc Programme

We're currently looking for hardworking scientists to join our innovative academic-style Postdoc program. This position is placed at AstraZeneca's dynamic R&D site in Gothenburg, Sweden, where you will be in a global pharmaceutical environment, contributing to live projects right from the beginning. You'll take part in a comprehensive training programme, including a focus on drug discovery and development, given access to our existing Postdoctoral research, and encouraged to pursue your own independent research in our ground-breaking laboratories. This an exciting and newly expanding programme spanning a range of therapeutic areas across a wide range of fields.

About the Opportunity

Working with professionals from multidisciplinary backgrounds at AstraZeneca, together with a world class academic mentor, Professor Didier Trono from Ecole Polytechnique Fédérale de Lausanne, you'll have access to innovative laboratory facilities and be able to perform cutting edge research in this understudied field of respiratory biology. You will be part of a multifaceted environment with highly dedicated scientists striving to make a difference to patients. In this role, you will design, perform, analyze and interpret experiments to study the expression and regulation of LINE-1 retroelements using cell lines and primary cells from lung origin. Interpreting and integrating your data, with respect to publicly available datasets to generate additional insights. You'll be empowered and supported to drive the success of your project, publish papers and achieve your goals. In addition, you will gain valuable insights in drug discovery and development.



Qualification, Skills & Experience

Required:

* PhD with broad experience in genetic profiling studies including data interrogation, with hands on expertise in RNA-Seq.
* Strong hands-on skills in basic biochemical and molecular techniques including cell culture, quantification of mRNA (qPCR) and protein expression, ELISA, Western blot, assay development, and over-expression, knock-down techniques.
* Highly organized and self-motivated, with the ability to work independently as well as collaboratively.



Desirable:

* Basic understanding of respiratory diseases.
* Previous experience in studying retroelements.
* Previous experience in inducing and monitoring cell senescence.
* Publication(s) in peer-reviewed journals.



This is a 3-year programme. 2 years will be a Fixed Term Contract, with a 1-year extension which will be merit based.



Are you already imagining yourself joining our team? Good, because we can't wait to hear from you.



Advert Opens: 19 October 2021

Advert Closes: 28 November 2021



Where can I find out more?



AstraZeneca's Postdoc Programme: https://careers.astrazeneca.com/postdocs-astrazeneca

Life at AstraZeneca: https://careers.astrazeneca.com/life-at-astrazeneca

Sustainability at AstraZeneca: https://www.astrazeneca.com/sustainability.html