Postdoctor in genetic interactions between mitochondrial and nuclear DNA

The University of Gothenburg tackles society’s challenges with diverse knowledge. 56 000 students and 6 600 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract researchers and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.The Institute of Biomedicine is involved in both research and education. In both of these areas, we focus on fundamental knowledge of the living cell – what it consists of, how it works, how its function is directed by the genetic material, and how it interacts with various kinds of micro-organisms. Using this knowledge, we try to elucidate the causes of diseases, and find new ways to diagnose and treat them.

The Institute is composed of the following four departments:


• The Department of Infectious Diseases
• The Department of Microbiology and Immunology
• The Department of Medical Biochemistry and Cell Biology
• The Department of Laboratory Medicine

At present, the institute has about 360 employees and approximately 450 million SEK in total assets

Subject area 
Genetic interactions between mitochondrial and nuclear DNA.

Subject area description 
This project aims to how yeast cells manages misfolded proteins, including human disease proteins, through genetic interactions between the mitochondrial and nuclear genomes to coordinate their protein quality control systems (PQC).

Duties 
The postdoctoral project consists of research and supervision. The research entails in-depth analysis of yeast PQC and protein aggregation using molecular, genetic, and biochemical tools. Microscopy including single-cell, as well as, ensemble analysis is a prominent part of the assignment. The project will also include genome-wide analysis of genetic interactions between the mitochonsrial and nuclear genomes as well as synthetic genetic array technology, the construction of new yeast strains suitable for microscopic analysis of protein aggregation.

Eligibility 
To be eligible for appointment as a postdoc, the applicant is required to have a doctoral degree, a doctoral degree in art or a foreign degree that is deemed to be equivalent to a doctoral degree. This eligibility requirement must be met before the employment decision is made. 

In the first instance, those who have completed their degree no more than three years prior to the end of the application period shall be considered. Those who have completed their degree more than three years prior to the end of the application period may also be considered in the first instance if special grounds exist. Special grounds relate to leave of absence due to illness, parental leave, commissions of trust within union organisations, service within the defence services or other similar circumstances, as well as clinical service or service/assignment relevant to the subject area.   

Assessment criteria 
We are looking for a scholar with well-documented merits in yeast (Saccharomyces cerevisiae) molecular biology, including genetics and strain constructions. The successful applicant should have experience in microscopy including single-cell analysis. Documented (peer-reviewed original papers) expertise in working with yeast protein quality control/protein aggregation is considered advantageous.

Regulations for the evaluation of qualifications for academic positions are given in Chapter 4, Section 3 - 4 of the Higher Education Ordinance

Employment 
The employment is full time and temporary, two years with the possibility of one year's extension, with placement at the Institute of Biomedicine. First day of employment as agreed.

Selection process 
How to apply: https://www.gu.se/en/work-at-the-university-of-gothenburg/how-to-apply 

Contact information 
If you have any questions about the position, please contact professor Thomas Nyström, phone: +4631-7862582, mail: thomas.nystrom@cmb.gu.se

Unions 
Union representatives at the University of Gothenburg can be found here: https://www.gu.se/om-universitetet/jobba-hos-oss/hjalp-for-sokande 

Application 

Submit your application via the University of Gothenburg’s recruitment portal by clicking the “Apply” button. It is your responsibility to ensure that the application is complete as per the vacancy notice, and that the University receives it by the final application deadline.  

The application should contain:


• A cover letter giving a brief description of previous research experience, and a motivation to why you are applying
• A CV including a list of publications
• Proof of completed PhD
• Contact details of two references

Applications must be received by: 2024-09-19

Information for International Applicants 

Choosing a career in a foreign country is a big step. Thus, to give you a general idea of what we and Gothenburg have to offer in terms of benefits and life in general for you and your family/spouse/partner please visit: 

https://www.gu.se/en/about-the-university/welcome-services 
https://www.movetogothenburg.com/ 

The University works actively to achieve a working environment with equal conditions, and values the qualities that diversity brings to its operations.

Salaries are set individually at the University.

In accordance with the National Archives of Sweden’s regulations, the University must archive application documents for two years after the appointment is filled. If you request that your documents are returned, they will be returned to you once the two years have passed. Otherwise, they will be destroyed.

In connection to this recruitment, we have already decided which recruitment channels we should use. We therefore decline further contact with vendors, recruitment and staffing companies.