Postdoctoral fellow in cell biology with special emphasis on protein qualit

The University of Gothenburg tackles society's challenges with diverse knowledge. 37 000 students and 6 000 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract scientists and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.

The Institute of Biomedicine is involved in both research and education. In both of these areas, we focus on fundamental knowledge of the living cell - what it consists of, how it works, how its function is directed by the genetic material, and how it interacts with various kinds of microorganisms. Using this knowledge, we try to elucidate the causes of diseases, and find new ways to diagnose and treat them. The Institute is composed of the following five departments: . The Department of Infectious Diseases . The Department of Microbiology and Immunology . The Department of Pathology and Genetics . The Department of Clinical Chemistry and Transfusion Medicine . The Department of Medical Biochemistry and Cell Biology At present, the institute has about 350 employees and approximately 290 million SEK in total assets. This project aims to decipher how the osmotic stress responses and the Hog1-regulated network of genes affect and control protein homeostasis in the yeast Saccharomyces cerevisiae. The project further aims to study how this network is affected by cellular aging and, in turn, how the Hog1-dependent regulon, is influencing protein quality control and cellular lifespan. The postdoctoral project consists of research and research supervision. The research entails indepth analysis of yeast signaling and protein aggregation using molecular, genetic, and biochemical tools. Microscopy analysis of protein aggregation is a prominent part of the assignment. The project will also include bioinformatics, systems biology and functional genomic approaches.

Eligibility: An achieved doctoral degree is compulsory for a position as postdoctor at Göteborg University. The doctoral thesis shall be in a relevant area according to the specific position stated here. Since a position as postdoctor aims to give new holders of the doctorate the opportunity mainly to strengthen and develop their scholarly proficiency, we aim for those who have a doctoral degree not older than 3 years counting from last date of application. The qualifications for academic positions are given in Chapter 4, Section 3 - 4 of the Higher Education Ordinance. Assessment: We are looking for a scholar with well-documented merits in yeast (Saccharomyces cerevisiae) molecular biology, including genetics, systems biology, bioinformatics, and functional genomics. The successful applicant should have experience in microscopy including analysis of protein aggregation, single cells analysis, FRAP, FCS, and FLIP. Documented (peer-reviewed original papers) expertise in working with yeast Hog1-regulated network and osmotic stress is considered advantageous. Regulations for the evaluation of qualifications for academic positions are given in Chapter 4, Section 3 - 4 of the Higher Education Ordinance.