Postdoctoral fellow in Hematology

The University of Gothenburg tackles society’s challenges with diverse knowledge. 56 000 students and 6 600 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract scientists and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.The research group develops cancer immunotherapies and has contributed to the development of histamine dihydrochloride and IL-2 as a relapse preventive therapy in acute myeloid leukemia. The group collaborates with surgery and hematology units at the Sahlgrenska University hospital and participates in clinical trials. For more information see: http://www.cancercenter.gu.se/research/anna-martner/

Chronic and acute myeloid leukemia are the two main forms of myeloid leukemia. Chronic myeloid leukemia (CML) is a homogenous form of blood cancer, where a t(9:22) translocation gives rise to a BCR-ABL fusion gene encoding a constitutively active tyrosine kinase that drives the proliferation and accumulation of relatively mature granulocytes. CML is treated by specific tyrosine kinase inhibitors that efficiently block the proliferation of malignant cells. However, most patients need life-long therapy, as residual CML stem cells may cause disease relapse if treatment is interrupted.

Acute myeloid leukemia (AML) is a heterogenous disease where multiple translocations and mutations can give rise to rapidly proliferating clones of malignant leukemic cells. In the acute phase, AML is treated by rounds of chemotherapy, which often eradicates the majority of malignant cells leading to complete remission. However, within a few years, most patients experience leukemic relapses, which likely are caused by residual leukemic stem cells. Hence, in both CML and AML targeting residual leukemic stem cells is an unmet medical need.

Subject area 
Hematology.

Subject area description 
The aim of this research project is to, by a multi-omic approach, characterize leukemic stem cells in CML and AML

Duties 
The project comprises multi-omic analyzes of clinical samples from patients with CML and AML obtained before or after tyrosine kinase or chemotherapy treatment, respectively. The methods that will be utilized include FACS-sorting, BD Rhapsody analysis and bioinformatic analysis in R. The leukemic stem cells may also be evaluated functionally in xenograft mouse models.

Eligibility 
The eligibility criteria for employing teaching staff are set out in Chapter 4 of the Higher Education Ordinance and in the Appointment Procedure for Teaching Posts at the University of Gothenburg.

To be eligible for appointment as a postdoc, the applicant is required to have a doctoral degree, a doctoral degree in art or a foreign degree that is deemed to be equivalent to a doctoral degree. This eligibility requirement must be met before the employment decision is made.

In the first instance, those who have completed their degree no more than three years prior to the end of the application period shall be considered. Those who have completed their degree more than three years prior to the end of the application period may also be considered in the first instance if special grounds exist. Special grounds relate to leave of absence due to illness, parental leave, commissions of trust within union organisations, service within the defence services or other similar circumstances, as well as clinical service or service/assignment relevant to the subject area.

Assessment criteria 
The applicant is expected to hold a doctoral degree in immunology, microbiology with focus on immunology, molecular biology, hematology or oncology.

Documented experience of flow cytometry, including single cell FACS-sorting, molecular biology techniques, multi-omics, preferably in a BD Rhapsody system, bioinformatic analysis of singe cell transcriptomic data, preferably in R, are most important.

It is also a merit to have passed a course in animal handling and to have experience form experimental animal models

Regulations for the evaluation of qualifications for academic positions are given in Chapter 4, Section 3 - 4 of the Higher Education Ordinance. 

Employment 
The employment is full time and temporary, three years, with placement at the Institute of Biomedicine. First day of employment as agreed.

Selection process 
How to apply: https://www.gu.se/en/work-at-the-university-of-gothenburg/how-to-apply

Contact information 
If you have any questions about the position, Anna Martner, PhD, senior lecture, 0736-517644, anna.martner@gu.se.

Unions 
Union representatives at the University of Gothenburg can be found here: https://www.gu.se/om-universitetet/jobba-hos-oss/hjalp-for-sokande 

Application 

Submit your application via the University of Gothenburg’s recruitment portal by clicking the “Apply” button. It is your responsibility to ensure that the application is complete as per the vacancy notice, and that the University receives it by the final application deadline.  

The application should contain:


• A cover letter giving a brief description of previous research experience, and a motivation to why you are applying
• A CV including a list of publications
• Proof of completed PhD
• Contact details of two references

Applications must be received by: 2023-05-30

Information for International Applicants 

Choosing a career in a foreign country is a big step. Thus, to give you a general idea of what we and Gothenburg have to offer in terms of benefits and life in general for you and your family/spouse/partner please visit: 

https://www.gu.se/en/about-the-university/welcome-services 
https://www.movetogothenburg.com/ 

The University works actively to achieve a working environment with equal conditions, and values the qualities that diversity brings to its operations.

Salaries are set individually at the University.

In accordance with the National Archives of Sweden’s regulations, the University must archive application documents for two years after the appointment is filled. If you request that your documents are returned, they will be returned to you once the two years have passed. Otherwise, they will be destroyed.

In connection to this recruitment, we have already decided which recruitment channels we should use. We therefore decline further contact with vendors, recruitment and staffing companies.