Postdoctoral researcher

Postdoctoral Researcher: Therapeutic strategies to target neutrophil extracellular traps in bronchiectasis
Location: Gothenburg, Sweden
Type of contract: 2-year temporary contract



Are you a highly motivated bioscientist with passion for innovation and applied science? Are you interested in conducting an academic-style postdoc in a pharmaceutical industry environment? Then this may be a perfect role for you!



We are currently looking for a Postdoctoral researcher to join the Bioscience COPD IPF Department within Early Respiratory and Immunology (R&I) to carry out a 2-year project aimed to define targetable mechanisms to modify neutrophil responses in respiratory disease. This position will be on-site at AstraZeneca's dynamic R&D site in Gothenburg, Sweden.

At AstraZeneca, Postdocs play a crucial role in advancing scientific knowledge and driving innovation. The Bioscience COPD/IPF department consist of 7 teams spread across Sweden, UK and US and our focus is primarily to progress projects within our portfolio, but it also includes work to increase our knowledge of chronic respiratory diseases and to support the identification of novel therapeutic targets.



What you´ll do:
As a Postdoc, you will conduct a research project aimed to advance our understanding of the role of neutrophils in bronchiectasis. More specifically, you will work towards identifying stimuli-specific regulatory pathways and therapeutic targets to block neutrophil extracellular trap formation and to achieve an immunomodulatory effect in a disease-relevant context.

Your work will predominantly involve human in vitro cell models. You will be using state-of-the art technology and be supported by experts in the field. At AstraZeneca, you will be mentored by Lina Odqvist, Bioscience Director with over 10 years in the company and with experience in neutrophil research. You will also be supported by an academic mentor at the University of Dundee, Professor James Chalmers, an acknowledged world-leading expert in bronchiectasis and neutrophil research.



Our ambition is for you to publish this research in high impact journals and share your findings via conference presentations at both national and international level. This project will also drive our ongoing research in chronic respiratory diseases forward and hopefully impact future therapeutic directories. As a Postdoc at AstraZeneca, you'll be empowered and supported to drive the success of your project, publish papers and achieve your goals. In addition, you will gain valuable insights in drug discovery and development of leadership skills.

Essential requirements for the role:

* PhD in a life science discipline
* Strong hands-on skills in basic molecular biology techniques including quantification of protein expression (ELISA, Western blot) and mRNA (qPCR), gene silencing and overexpression, imaging etc
* Extensive expertise in human in vitro cell culturing and functional cell models
* Excellent written and oral communication skills
* Strong organizational skills, problem-solving attitude, and self-motivation
* Publication record
* Ability to work independently, but also good networking and team player skills, incorporating views of others in your research and communication

Desirable requirements for the role:
* Experience in the isolation, culturing and analysis of primary human cell cultures, including immune cells. Application of co-culture models
* Knowledge and practical experience in neutrophil biology
* Previous experience in studying respiratory diseases

Why AstraZeneca?
At AstraZeneca we turn ideas into life changing medicines and strive to continuously meet the unmet needs of patients worldwide. Working here means being entrepreneurial, thinking big, and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you're our kind of person.



What's next?
Are you already imagining yourself joining our team? Good, because we can't wait to hear from you. Welcome with your application (including CV and cover letter) no later than September 15th, 2024.



Find Out More:
AstraZeneca: https://www.astrazeneca.com/
Life at AstraZeneca: https://careers.astrazeneca.com/life-at-astrazeneca
This is what we're made of: https://www.youtube.com/watch?v=pmFx_jr2eFo&t=2s