Postdoctoral researcher in tumor immunology

Do you want to contribute to top quality medical research?
We are looking for an ambitious postdoc with solid single-cell immunology skills to join our highly accomplished team of immunologists in a project funded by the Swedish Cancer Society and Karolinska Institutet.

We offer a stimulating environment in a rapidly moving research frontier.

The Mjösberg group (https://mjosberglab.wixsite.com/ilcs and https://ki.se/en/medh/jenny-mjosberg-group) studies the development, regulation and function of innate lymphoid cells (ILCs), in humans, and how these cells contribute to pathology in mucosal organs such as the lung and gut. The studies are translational as they involve advanced basic molecular and cellular immunological investigations of precious human tissue samples to discover novel disease mechanisms, therapy targets and improved strategies for personalized treatment. The Mjösberg group consists of three PhD students, four postdocs and a lab manager working closely together with clinical partners at several Swedish hospitals and laboratory facilities at Science for Life Laboratories (SciLifeLab), Karolinska Institutet and abroad. Your Mission
The Mjösberg group is internationally recognized as a leader in the field through several high impact publications in recent years (Nat Immunol 2016, JACI 2018, JACI 2019, Nat Comm 2020 etc). In particular, the postdoc will continue the successful line of investigations utilizing single-cell RNA sequencing (scRNA-seq) to dissect human intestinal mucosal ILC and T cell biology in health and disease. The postdoc will be a part of the Center for Infectious Medicine (CIM), Karolinska Institutet, which is a nationally leading and internationally competitive center for human translational immunology and infectious diseases research. The center consists of approximately 25 graduate students and 25 postdocs organized around 14 independent research groups.

The project involves generation of scRNA-seq (SMARTseq and 10X genomics) data as well as multicolor flow cytometry data of human intratumoral ILCs and T cells in colorectal cancer. The postdoc will work closely together with gastrosurgeons at Karolinska University Hospital. The data will be analyzed in close collaboration with bioinformaticians at SciLifeLab. As this is a team effort, excellent communication skills are essential, as is proven ability to work in multidisciplinary teams. It is expected that the postdoc also supervise students and other researchers if necessary, as well as contribute to common lab duties.

Your profile
The candidate must hold a PhD equivalent to a Swedish doctoral degree in the field of immunology. The candidate must fully master multidimensional (>20 parameters) flow cytometry analysis and sorting, as well as be experienced in scRNAseq. Experience in isolation and in vitro culturing of primary immune cells is a requirement, as is basic functional in vitro assessments of immune cell function such as intracellular cytokine stainings, ELISA etc. The candidate should be familiar with R software and have some experience analyzing scRNAseq data. The candidate should have a strong publication track-record. The candidate should be self-motivated, have good communications skills and a proven ability to interact effectively and work productively in an interdiciplinary team. Fluency in English is a requirement as well as some basic skills and willingness to learn Swedish.

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant's main supervisor, director or equivalent.

What do we offer?
Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote better health for all. At Karolinska Institutet, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. Karolinska Institutet is a state university, which entitles employees to several benefits such as extended holiday and a generous occupational pension. Employees also have free access to our modern gym and receive reimbursements for medical care.


Location: Flemingsberg

Application

An employment application must contain the following documents in English or Swedish:

- A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
- A complete list of publications
- A summary of current work (no more than one page)

Welcome to apply at the latest 31/10 2020

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all