Preclinical and Translational PK & PKPD Scientist

Are you an expert in mathematical modelling? Would you like to apply your expertise in a company that is accelerating innovative science and turns ideas into life changing medicines? Join us to be part of the development of future treatments of Cardiovascular, Renal and Metabolic diseases!

Working at AstraZeneca means being entrepreneurial, thinking big and working together to make the impossible a reality. We are now recruiting a highly skilled and passionate scientist with expertise in mathematical modelling, preferably applied in the field of pharmacokinetics-pharmacodynamics (PKPD), to join the Modelling & Simulation team within the Early Cardiovascular, Renal and Metabolism (CVRM) therapeutic area at AstraZeneca. The position is placed at AstraZeneca's dynamic R&D site in Gothenburg, Sweden.

Early CVRM is one of the three main therapeutic research areas within AstraZeneca which deliver candidate drugs into late-stage clinical development. Early CVRM is a global function with research units in Gaithersburg, US, Cambridge, UK and Gothenburg, Sweden. The Modelling & Simulation team is part of the Drug, Metabolism and Pharmacokinetics (DMPK) department and based in AstraZeneca's world-class R&D center in Gothenburg Sweden. DMPK interacts with other functions in supporting Early CVRM projects all along the value chain, from target selection all the way to market launch and Life cycle management.

What you'll do

With a true passion for science you will support our portfolio within the CVRM disease area. You will deliver translational quantitative/PKPD input for a broad range of drug modalities from target identification to life-cycle management. The position can be at Senior Scientist or Associate Principal Scientist level depending on the experience of the successful candidate. Responsibilities includes:

* Define and deliver the translational quantitative/PKPD strategy in projects from target identification to life-cycle management
* Identify the appropriate mathematical modelling approach (e.g. traditional PKPD modelling, non-linear mixed effects modelling, quantitative systems pharmacology) to deliver the aforementioned
* Design preclinical PKPD studies, contribute to estimation of safety margins and report results and interpretations to project teams and internal governance bodies
* In collaboration with key functions (e.g. bioscientists, translational scientists, safety scientists, clinical pharmacologists and clinical pharmacometricians) integrate the appropriate data to predict human pharmacokinetics, efficacious human drug exposure, human longitudinal response (e.g. biomarker and disease effects), and human dosing regimen
* Communicate scientific progresses both externally and internally

Essential for the role

The successful candidate is expected to have a solid PKPD understanding and hands-on mathematical modelling experience (e.g. empirical PKPD models, in vitro-in vivo translation, non-linear mixed effects models, mechanistic systems pharmacology models).

* PhD in pharmacokinetics, pharmacology or related field, with focus on mathematical modelling of PKPD data, ideally in a preclinical/translational setting
* Specialist in PK and PKPD data analysis, interpretation, and reporting, including hands-on experience with modelling software (e.g. Phoenix, Matlab, Monolix, R, NONMEM, or similar)
* Excellent interpersonal skills, and ability to work in cross-functional teams as well as independently
* Scientific leadership evidenced by a publication track record and ability to independently lead the drafting and review of publication manuscripts
* Excellent communication skills in English, both verbal and in writing

Desirable for the role

* Experience in pharmaceutical R&D
* Experience in defining quantitative modelling strategies across several therapeutic modalities (e.g. small molecules, oligonucleotides, peptides, proteins, antibodies)

So, what's next?

Are you already imagining yourself joining our team? Good, because we can't wait to hear from you!

For more information about the position please contact recruiting manager Christine Ahlström at christine.ahlstrom@astrazeneca.com

Welcome with your application no later than December 20, 2020

Where can I find out more?

Our Gothenburg site: Link

Life in Gothenburg: Link

Culture and atmosphere of the Gothenburg site: Link



Why AstraZeneca?

Our Gothenburg site is one of AstraZeneca's three strategic science centers. We thrive in a multinational environment working cross-functionally across the globe with AstraZeneca colleagues as well as academic and industry partners. Our way of life is to foster a working environment that nurtures, collaboration, openness and innovation. Therefore, we have created space for meetings, socializing and relaxation, where spontaneous meetings can give birth to new innovations. The unexpected ideas or thoughts that can come from a chat over something as simple as a cup of coffee or a stroll on our "walk and talk" meeting trail.