Preclinical DMPK lead

• Are you a scientist with expertise in drug discovery? Would you like to apply your expertise in a global company that follows the science and turns ideas into life-changing medicines? Then you could be the new colleague we are looking for! Join us as a Preclinical DMPK Project Lead!

About the position
We are now looking for an experienced and motivated individual to join our team as a Senior Research Scientist or an Associate Principal Scientist, depending on your level of professional experience and capabilities. You will be part of the DMPK Department within Early Respiratory & Immunology (R&I) and this position is placed at AstraZeneca’s vibrant R&D site in Gothenburg, Sweden, one of AstraZeneca’s three strategic science centers.
At AstraZeneca Respiratory & Immunology (R&I), we're proud to have an outstanding workplace culture that encourages innovation and teamwork. We are united by our vision to push the boundaries of DMPK science to transform ideas into medicines for R&I patients. Employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.

Responsibilities
• Responsible for leading all DMPK related activities, including coordinating and engaging with internal and external DMPK colleagues and collaborators, on project related activities
• Deliver DMPK input and data to projects within agreed timelines and to the right quality to ensure that DMPK challenges are thoroughly assessed and resolved
• Contribute to the design of preclinical in vivo PD studies to answer crucial project questions
• Accountable, together with other functions such as Medicinal Chemistry, Bioscience and Safety, for compound design and effective cross-discipline optimization
• Apply an understanding of DMPK and PKPD to support/influence project progression and strategy as well as providing the framework for human dose predictions
• Prepare clear presentations related to the above for internal governance interactions

Your profile
Essential for the role
• Degree/MSC in chemistry, biopharmaceutics, pharmacokinetics or equivalent experience in a relevant field
• Formal training or proven experience of working with pharmacokinetics and drug metabolism and a good understanding of pharmacodynamics
• Understanding of physicochemical properties and their influence on ADME properties and the ability to apply this understanding to design of new molecules
• Have (at least) basic PK modelling skills, experience of human PK and dose prediction, as well as an understanding of disease biology and PKPD
• Experience of working in preclinical DMPK
• Experience from drug discovery, cross-functional working and molecule/project progression
• Ability to engage and collaborate across boundaries with a problem solving attitude and focus on delivery
• Strong communication skills

About the organisation
This position is a consultant assignment at AstraZeneca via QRIOS Life Science & Engineering in Göteborgfor for one year. During this time you will be employed by QRIOS Life Science & Engineering.
QRIOS employs curious experts in IT, Life Science and Engineering. We want to continue to attract the best employees, to continue to support our partners with the important competences you require. We are a recruitment and consulting company that is strongly inspired by those who never stop looking for new solutions. As we say, QRIOS MINDS GO FURTHER