Preclinical DMPK lead (Pharmacology, data mining & programming)

DMPK Department with Early Respiratory & Immunology

Hays Life Sciences is now looking to recruit a Preclinical DMPK lead (with focus on Pharmacology, data mining and programming) to join the DMPK Department with Early Respiratory & Immunology for 1-year contract assignment at AstraZeneca in Gothenburg.

Are you a scientist with expertise in drug discovery? Would you like to apply your expertise in a global company that follows the science and turns ideas into life-changing medicines? Then you could be the new colleague we are looking for! Join us as a Preclinical DMPK Project Lead!

We are now looking for an experienced and motivated individual to join our team as a Senior Research Scientist or an Associate Principal Scientist, depending on your level of professional experience and capabilities. You will be part of the DMPK Department within Early Respiratory & Immunology (R&I) and this position is placed at AstraZeneca's vibrant R&D site in Gothenburg, Sweden, one of AstraZeneca's three strategic science centers.
At AstraZeneca Respiratory & Immunology (R&I), we're proud to have an outstanding workplace culture that encourages innovation and teamwork. We are united by our vision to push the boundaries of DMPK science to transform ideas into medicines for R&I patients. Employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.

What you'll do
The right candidate would have the possibility to join several ongoing projects and activities being developed at present in our department. Several of our activities are linked to real drug projects which are active in our pipeline, which offers a rare opportunity for the right candidate to participate in the discovery and development of the drugs of the future. The right candidate could join different ongoing projects performing different tasks, depending on own background and skills. One task is looking into previously conducted preclinical in vivo studies as well as clinical studies (by external partners) where public information is available. By means of applying pharmacokinetic and basic statistical knowledge (some extent of training can be provided), valuable information can be extracted for the benefit of several early drug discovery projects. Given the candidates profile, another task would be to develop a tool (a graphical user interface) for performing uncertainty analysis of predicted Dose to Man, where external public information can be of major importance.
We are looking for a person with both a sense for quality and details, an interest in data mining, programming and of course a profound interest in pharmacokinetics as well as pharmacology. This is an opportunity to learn how to apply the knowledge into real world data and thrive in the vibrant research site in Gothenburg.

Main Duties and Responsibilities

* Responsible for search of external and internal data on pharmacokinetics and biological response, for compounds of interest for ongoing projects. In scope is both preclinical and clinical data and sifting out information through various means.
* Responsible for assessment of panned out data through knowledge in pharmacokinetics, statistics, pharmacology and PKPD modelling.
* Contribute to the design of preclinical in vivo and in vitro studies, to answer crucial project questions.
* Deliver input to projects within agreed timelines and to the right quality to ensure that challenges are thoroughly assessed and resolved
* Apply an understanding of PK and PKPD to support/influence project progression and strategy as well as providing the framework for human dose prediction
* Prepare clear presentations related to the above for internal governance interactions
* Depending on the candidate's profile the candidate is expected to contribute to the development of a graphical user interface to perform uncertainty analysis of Dose to Man predictions

Essential for the role

* Degree/MSC in science with background in life-sciences, Pharmacy, Biology, Biochemistry, Medical Biosciences, Engineering, programming or similar
* PK and PKPD understanding (preferable with some modelling experience)
* Desirable some statistical and programming knowledge
* Excellent interpersonal skills that lead to successful collaborative working relationships and ability to work independently in cross-functional teams on a day to day basis.
* Good communication skills in English, both verbal and in writing are required
* Strong communication skills