Preclinical & Translational PK & PKPD Scientist

The arena
We are now looking for a Preclinical and Translational PK and PKPD Scientist for a position that will focus on modelling and simulation (M&S) techniques to help drug discovery projects to understand and integrate in-vitro and in-vivo absorption, distribution and metabolism (ADME) properties and pharmacokinetic (PK) and pharmacodynamic (PD) properties, including biomarkers for mechanism of action.

The role will be based in Gothenburg, Sweden

Major responsibilities:
Define and deliver the translational quantitative/PKPD strategy for efficacy and target safety, in projects from target identification to life-cycle management.
Identify the appropriate M&S approach (e.g. traditional PKPD modelling, non-linear mixed effects modelling, quantitative systems pharmacology) to deliver the aforementioned.
Design preclinical PKPD studies and report results and interpretations to project teams and internal governance bodies.
In collaboration with key functions (e.g. bioscientists, translational scientists, safety scientists, clinical pharmacology and clinical pharmacometricians) integrate the appropriate data to predict human pharmacokinetics, efficacious drug exposure, human longitudinal response (e.g. biomarker and disease effects), and human dosing regimen.
Contribute to estimation of safety margins and make recommendations and predictions on human efficacious dose and exposure.
Deliver drug-drug interaction (DDI) predictions and risk assessments to project teams. Contribute proactively to an innovative working environment where improvements and new ideas are adopted and freely shared. Continuously display scientific progress externally and internally.

Minimum Requirements:
PhD or equivalent level of experience in mathematical modelling and simulation of PK/PD, biological systems, quantitative systems pharmacology and ideally in a preclinical/translational setting
Specialist in modelling and simulation tools such as Matlab, R, NONMEM, WinNonlin/Phoenix NLME, SimCyp
Experience of defining quantitative modelling strategies across several therapeutic modalities (e.g. small molecules, oligonucleotides, proteins, antibodies)
Track record of ability to meet timelines to pre-specified quality and cost
Understanding of integrative aspects of DMPK and pharmacology/safety aspects of drug discovery and development
Experience in pharmaceutical R&D and experience in operating cross-functionally

About AstraZeneca

AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of prescription medicines for some of the world's most serious diseases. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we're proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.


More information

For more information about the position please contact: Rasmus Jansson Löfmark at +46 31 7761109.

Welcome with your application no later than May 29, 2016.

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