Principal Scientist, Computational Chemistry

Would you like to bring your expertise and passion for Computational Chemistry and Medicinal Chemistry to a company that push the boundaries to unlock the power of what science can do? Join us to discover future treatment of Cardiovascular, Renal and Metabolic diseases!

At AstraZeneca, you will be empowered to be innovative and creative where difference is valued. We thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment.

We now offer an exciting opportunity for an experienced Computational Chemist to join the Medicinal Chemistry Department within the Cardiovascular, Renal and Metabolism (CVRM) therapeutic area, one of AstraZeneca´s core therapy areas. The Medicinal Chemistry Department within CVRM is a critical player in the discovery and design of our drug molecules and in identifying and validating novel biological targets. The position is placed at AstraZeneca's dynamic R&D site in Gothenburg, Sweden or Cambridge, UK and comes with and comes with competitive salary and benefits.

What you'll do

As a Computational Chemist you will have a profound impact on multiple projects across the CVRM portfolio covering many different modalities (small molecules, peptides, PROTACs, and oligonucleotides). As part of our fantastic, fast-paced computational chemistry team you will operate in a highly cross disciplinary environment in close collaboration with scientists from the Chemistry, Bioscience, DMPK and Pharmaceutical Sciences departments. You will have a key role in modelling, analysis of large datasets, drug design and you will be a significant contributor to discovery project progression. You will also be involved in building and driving our future design capabilities to tackle difficult targets and implementation of Augmented Drug Design across our portfolio. You will join a great team of highly-skilled and experienced computational chemists mastering all contemporary design areas like MD, FEP, ML and AI.

* You will simultaneously impact multiple discovery projects by efficiently and pro-actively applying a wide variety of computer-aided drug design approaches
* With your solid experience and excellent knowledge of modern computational chemistry you will identify and drive our future design capabilities
* You will be expected to plan, write and publish high quality scientific papers

Essential for the role

In this key role you will bring your solid computational chemistry experience to the drug discovery project portfolio. We are looking for a drug hunter with a PhD (or equivalent experience) in computational chemistry and industry experience from drug design, biophysics or related field. You have a high degree of independence and a proven record of excellence in a number of computer-aided drug design techniques to assist in target identification and advancement of discovery programs. In addition you will have:

* Solid knowledge of computer-aided drug design and modern medicinal chemistry.
* Expertise in using standard computational chemistry software.
* Ideally experience of computational chemistry applied to new modalities (e.g. peptides, PROTACs or oligonucleotides).
* Expertise in biophysics, structural modeling and methods to study protein dynamics.
* Knowledge in scientific computing, and programming skills (e.g. Python) is an advantage.
* Expertise in machine-learning methods is a plus.
* Excellent communication skills in English is required.

If you have the ability to influence both people and science and thrive on team work in a multidisciplinary environment, you will fit right in at AstraZeneca!

So, what's next?

Are you already imagining yourself joining our team? Good, because we can't wait to hear from you!

For more information please contact recruiting manager Dr. Anders Hogner, Anders.Hogner@astrazeneca.com.

Welcome with your application no later than November 4th, 2021, 2021

Where can I find out more?

Our Gothenburg site: https://www.astrazeneca.com/our-company/our-locations/gothenburg.html

Our Cambridge site: https://www.astrazeneca.com/our-company/our-locations/cambridge.html#modal-generic

Life in Gothenburg: https://www.movetogothenburg.com/

Culture and atmosphere of the Gothenburg site: https://www.linkedin.com/feed/update/urn:li:activity:6496327311678410752/

Why AstraZeneca?

AstraZeneca is a global, innovation-driven biopharmaceutical company proud to provide a unique workplace culture that inspires innovation and cross-boundary collaboration. Within this environment employees are empowered to express diverse perspectives, and are made to feel valued, energized and rewarded for their ideas and creativity.