Principal Scientist in translational PKPD / systems pharmacology

We are looking for a highly experienced translational PK/PD scientist / systems pharmacologist to join our global team in Gothenburg.

Our stunning campus in Gothenburg is one of AstraZeneca’s three strategic science centers. The site is home to over 2,500 employees, from 50 different nationalities. Gothenburg includes the complete range of functions, and as such offers plenty of development opportunities for a wide range of professionals. Our science teams in Gothenburg collaborate with academic and industry partners in Sweden and globally. And the site itself has been designed with collaboration in mind. From the Coffee Lab to exercise areas, we’ve created a series of environments where innovation can happen.

As a Principal Scientist in translational PKPD / systems pharmacology you will be providing project teams with directions for applying computational biology and mathematical modelling approaches to predict drug efficacy in human populations. This will be done by evaluation of pharmacokinetic/pharmacodynamic (PKPD) relationships in the context of respiratory disease mechanisms through integration of biological data from various sources.

At AstraZeneca we turn ideas into life changing medicines. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality.

Main Duties and Responsibilities
- Define and deliver the preclinical, translational PKPD strategy for clinical efficacy in projects from Target Identification to Life Cycle Management and propose innovative approaches for improving therapeutic index.
- Generate hypotheses of biological mechanisms and work collaboratively with other functions as needed to build predictive models and test predictions.
- Keep up-to-date with and propose the implementation of scientific and technological developments in the area of Systems Pharmacology/Biology
- Leverage and integrate public and proprietary data from a variety of sources to develop mechanistic models of biological systems.
- Prepare presentations related to the above for internal governance bodies.
- Disseminate scientific achievements thorough conference attendance and preparation of manuscripts for research papers
- Consistently demonstrate scientific leadership and innovation driven by curiosity to continue to learn and improve and excel in core discipline.
- Ensure scientific and business decisions are based on strong science.
- Seek to understand the healthcare environment and external trends.
- Set high standards for self and others, making courageous choices to ensure success.

Essential Requirements
- Ph.D. in Engineering, Mathematics, Bioinformatics, Pharmacometrics, Systems Biology/Pharmacology or a related field, with 2+ years of mathematical modelling & Systems Pharmacology experience for biomedical/pharmaceutical industry and 3+ years post-doc positions or 5+ years in industry.
- Proven track record of successful work at the intersections of bioinformatics, clinical science and PKPD to answer questions relating to understanding disease mechanisms and prediction of drug efficacy in responding patient populations.
- Expert in general programming and data analysis tools/languages such as R, Matlab etc.
- Excellent written and verbal communication skills in English
- Strong influencing, networking and team working skills.

Leadership and behaviours
- Strong external scientific influence combined with smart risk taking.
- Role model external networking and enable excellent collaboration both internally and externally.
- Strong publication record and science communication.
- Coach and develop junior scientists.
- Encourage individual responsibility and initiative and work actively to anticipate and/or remove obstacles for oneself and others
- Communicate a common vision in an engaging and inspiring way. Able to translate strategy into cutting edge science.

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.

More than ever, science is accelerating our rate of understanding in a wide range of medical fields – and that’s only set to increase. As a global, science-led biopharmaceutical business, AstraZeneca is at the forefront of that evolution. That means an unparalleled product portfolio and a strong pipeline across all stages of the drug development process. Everything we do comes back to improving the health of our patients worldwide, and to make that happen we’re focusing on some of the most challenging diseases facing humanity today.

We have a highly collaborative culture, where you’ll be encouraged to push the boundaries of science while developing industry-recognised skills and experiences.