Principal Scientist - Integrated Bioanalysis

Are you an experienced scientist with a background in analytical biochemistry that holds expertise of developing mass spectrometric methods for the quantitative measurement of biotherapeutics? Do you also want to work in an excellent team with a common goal to push the boundaries of science? If yes, this might be your next challenge!

We are seeking a highly motivated Principal Scientist to join our Integrated Bioanalysis organisation as our new Associate Director based at AstraZeneca's vibrant R&D site in Gothenburg, Sweden. In this role, you will take a lead role in the lab designing and interpreting large molecule, anti-sense oligonucleotide and antibody drug conjugate mass spectrometry-based approaches for advancing our drug pipeline.

The position sits in our Discovery Bioanalysis Europe team which is part of the Clinical Pharmacology and Safety Sciences (CPSS) function and is responsible for the analysis of nucleotide, protein, monoclonal antibody and cell therapeutics and non-clinical safety biomarkers in biological and invitro samples generated in support of non GLP pharmacokinetic, pharmacodynamic and investigational safety studies. We have a diverse array of scientists working across many technologies to ensure delivery of critical assays and data analysis that drive go/no go decisions and ensure the right combination of medicines get to the right patient, in the right dose, at the right time.

What you'll do:
In this position you will lead mass spectrometry pharmacokinetics and proteomics biomarker activities in the laboratory to better understand drug actions and their association with pharmacodynamics. Your principle responsibility will be in the lab, designing, developing, and interpreting assays to support drug program transition through to lead candidate selection.

You will also be expected to represent the department on multidiscipline drug development teams, thus ability to support other technologies in the lab, especially ligand binding, PCR, branched-DNA and hybridisation ELISA assays will be a benefit. The role taker reports into the Head of Discovery Bioanalysis US and supervise associate(s) and be expected to take a lead role in pushing the boundaries of what is possible for mass spectrometry based bioanalyses in determining lead drug candidates.

Essential in the role:
This is a scientific leadership role providing bioanalysis strategic direction to the organisation. The position requires working as the group representative in multidiscipline teams where effective communication, provision of influential bioanalysis advice and outstanding record keeping skills are essential for success. This should go hand in hand with your attention to details, ability to think and act creatively, independently and within collaborations. You should also have;

* A strong background in analytical biochemistry / chemistry with extensive experience of developing mass spectrometric methods for the quantitative measurement of biotherapeutics such as antibody drug conjugates, oligonucleotides, peptides and proteins and biomarkers.
* Experience with chromatographic separation of various analytes by liquid chromatography.
* Proficiency with mass spectrometry and proteomic software.
* Proven ability to develop hypotheses and execute analysis plans for pharmacokinetics, pharmacodynamics and proteomics biomarker data.

Desirable in the role:

* Experience with advanced data analysis tools for analyzing and visualizing biomarker data.
* Operational experience with broader immunoassays e.g. ELISA, multiplex assays.
* A proven track record of publication in large molecule bioanalysis field. Innovative and influential leader, capable of developing strategic approaches to analytical challenges.

Why AstraZeneca?
Thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment. Be encouraged and supported to think creatively in our dynamic environment. Here we are free from fear of failure, free to ask the right questions and make bold decisions.

So, what's next? If this sounds like the job and place for you - welcome to apply today! We look forward to your application, but no later than 20th February, 2022.

Additional information:
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
Make a move to Global Gothenburg: https://www.youtube.com/watch?v=c-Iqbb4aw38