Research Scientist – Precise Genome Editing/Gene Therapy

At AstraZeneca we use scientific excellence as our foundation for driving success in our drug discovery pipeline. We underpin this with strong collaboration, clear direction and a focus on applying cutting-edge research to support drug discovery.

Om tjänsten
An exciting opportunity is now available to join the Precise Genome Editing team within Discovery Sciences, which has responsibility for the generation of novel genome editing technologies to support projects in all phases of the drug discovery pipeline. We have a focus on target identification, target validation, disease model generation and the therapeutic use of stem cells. We are seeking a scientist to join our team in Gothenburg Sweden, where the role will focus on generating genetically engineered mouse and cell models.

Dina arbetsuppgifter i huvudsak
Leveraging your strong knowledge and experience in genome editing you will have the opportunity apply your knowledge to gene therapy projects. This includes design of genome editing strategies, implement them using techniques including CRISPR/Cas9 and to validate the results. The role is focused on conducting laboratory-based activities, applying your knowledge and skills to drive project delivery and scientific innovation, participating actively in problem solving and working globally with Astrazeneca colleagues and collaborators.

Main duties include but are not limited to:
• Perform in vivo genetic manipulation and validation of engineered mouse models
• To assist in the design and implement delivery tools for genome editing-based strategies to generate in vitro and in vivo models
• To improve the efficiency of genome editing in vivo

Vem är du?
It is essential to have good social and communication skills, be collaborative and a strong team player and be an innovative thinker. Candidates should be able to work independently, take own initiatives and have a positive, goal oriented and problem-solving attitude. Good organisational, data management and documentation skills are required, and you should be comfortable in presenting your results. English language is required, both spoken and in writing.

Minimum experience
You should hold a degree or have significant relevant experience working in with small animals and a precise genome editing / molecular biology environment.

Essential skills for the job:
• Proficiency in ‘hands on’ in vivo work and delivery of reagents
• Strong knowledge and experience with core molecular biology techniques
• Experience with cell culture, preferable to have knowledge of primary cell culture

The following skills are highly desirable but not essential
• Expertise with CRISPR based editing and NGS analysis of genome editing outcomes

Om verksamheten
At AstraZeneca you will have the ability to make a more meaningful impact to patients’ lives around the globe, be empowered to be innovative and creative where difference is valued and build a long-term career by unlocking opportunities for lifelong learning.