Researcher

The University of Gothenburg tackles society’s challenges with diverse knowledge. 47 500 students and 6 400 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract scientists and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.

Our research group is performing research on enterotoxin-mediated diarrheal diseases, and we are particularly interested in studying the disease symptoms caused by the toxic effects of Cholera toxin (CT). Recently we have published findings that change the dogma of how CT binds to human cells. Whereas the glycolipid GM1 was the only previously known functional receptor for CT, we have discovered that CT intoxicates mice that lack GM1. https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006862

In addition, we have found that blocking fucosylated structures which do not express by GM1, efficiently inhibits binding to and CT-induced secretion from human intestinal biopsies. https://elifesciences.org/articles/09545. CT is also very immune-activating and thereby a potent oral adjuvant. Hence, our findings of novel receptors for CT opens up avenues for new blocking therapies as well as improved oral vaccines.

Job assignments
The researcher will establish organoid cultures from intestinal tissue and will then use molecular, biological, immunohistochemical and functional analyses, to determine how the organoids respond to different stimuli such as microbes, enterotoxins and cytokines. In addition, the researcher will participate in practical and theoretical supervision of other members of our research group. The researcher shall also summarize the results from their research and write reports.

Qualifications
PhD in a relevant subject. This assessment shall attach particular importance to documented qualifications for:

- knowledge within molecular biology, immunohistochemical techniques and physiological methods

- extensive experience within the areas of glycobiology, microbiology and/or immunology.

- scientific analysis, presentation and teaching verified by publications, conference abstracts and supervised students.

Documented experience in preparation of cells from tissues and subsequent in vitro experiments and/or practical cell culture experience with primary cells preferably organoids is desirable.

Employment
The employment is temporary (limited), 100% for 3 months and is placed at the Institute of Biomedicine. Starting date; as agreed. 

 

For further information regarding the position
Please contact Senior Lecturer Ulf Yrlid phone: +4631-7866225 email: ulf.yrlid@gu.se

Unions
Union representatives at the University of Gothenburg: http://www.gu.se/english/about_the_university/job-opportunities/union-representatives

How to apply
In order to apply for a position at the University of Gothenburg, you have to register an account in our online recruitment system. It is the responsibility of the applicant to ensure that the application is complete in accordance with the instructions in the job advertisement, and that it is submitted before the deadline. The selection of candidates is made on the basis of the qualifications registered in the application.

The application should contain proof of completed PhD.

The University of Gothenburg promotes equal opportunities, equality and diversity.

Salary is determined on an individual basis.

Applications will be destroyed or returned (upon request) two years after the decision of employment has become final. Applications from the employed and from those who appeal the decision will not be returned.

 


In connection to this recruitment, we have already decided which recruitment channels we should use. We therefore decline further contact with vendors, recruitment and staffing companies.