Researcher

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We are seeking a highly motivated, academically excellent and proactive researcher with a strong background in innate immunity to study the relation between the macrophage biology and metabolism, and to further develop this research area in the Anetta Härtlova lab (https://wcmtm.gu.se/research-groups/hartlova-group) at the Department of Microbiology and Immunology, Institute of Biomedicine at the University of Gothenburg.

Macrophages are key innate players driving inflammation, repair and resolution. Recently, metabolic state has been shown to be an important determinant for the switch between different macrophage phenotypes. Pro-inflammatory responses are in general dependent on glycolytic, rapid energy sources whilst resolution responses are more long lasting and generally dependent on oxidative lipid metabolism. In this project, we will investigate metabolic regulation of macrophages and how macrophage fitness contribute to the development of chronic diseases. This project is built on our recent work that unravel the role of macrophage scavenger receptor 1 (MSR1) in macrophage polarization (https://www.ncbi.nlm.nih.gov/pubmed/31028084). It is anticipated that the knowledge gleaned from the successful candidate’s research could ultimately be exploited to devise improved strategies to treat human chronic diseases such chronic lung or kidney disease.

Job assignments
The successful appointee will have the opportunity to develop their research career in a laboratory with a strong emphasis on training and mentorship. There will be opportunities to for the successful appointee to supervise postgraduate students and to apply for their own research funding. A broad skill base, including molecular (qRT-PCR, CRISPR-CAS9 technology) and cellular biology (isolation of mouse primary macrophages, IPSC-derived macvrophages, biochemistry (Immunoprecipitation, Western blotting), immunological assays (ELISA) and mass spectrometry-based proteomics is required.

Qualifications
Applicants should possess a PhD and a strong track record in innate immunity, macrophage biology and inflammation. Experience with the isolation and characterization of mouse primary and human IPSC-derived macrophages are required. Proficiency with molecular biology (qRT-PCR, CRISPR-CAS9), biochemistry (Western blotting, immunoprecipitation, mass spectrometry-based proteomics) basic immunological techniques (ELISA) is a need. Applicants should possess a strong desire to develop a successful and highly-productive research career in immunological research, excellent general research skills, a strong methodological background, excellent writing abilities, and the capacity to work both independently and within a team. Fluency in spoken and written English is essential.

Employment
The employment is limited (temporary) for 6 months, full-time and is placed at the Institute of Biomedicin. Starting date: as agreed. 

For further information regarding the position
Please contact Associate Senior Lecturer Anetta Härtlova mail: anetta.hartlova@gu.se phone +4631-786 6242

Unions
Union representatives at the University of Gothenburg:
https://www.gu.se/en/about-the-university/work-at-the-university-of-gothenburg/how-to-apply

Information for International Applicants
Choosing a career in a foreign country is a big step. Thus, to give you a general idea of what we and Gothenburg have to offer in terms of benefits and life in general for you and your family/spouse/partner please visit:

https://www.gu.se/en/about-the-university/welcome-services
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How to apply
In order to apply for a position at the University of Gothenburg, you have to register an account in our online recruitment system. It is the responsibility of the applicant to ensure that the application is complete in accordance with the instructions in the job advertisement, and that it is submitted before the deadline. The selection of candidates is made on the basis of the qualifications registered in the application.

Closing date: 21-11-19

The application should contain proof of completed PhD.

 

The University of Gothenburg promotes equal opportunities, equality and diversity.

Salary is determined on an individual basis.

Applications will be destroyed or returned (upon request) two years after the decision of employment has become final. Applications from the employed and from those who appeal the decision will not be returned.

 


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