Researcher in molecular pathology

Företagsnamn: Göteborgs universitet, institutionen för biomedicin
Besöksadress: Medicinaregatan 7B
Postadress: Box 440
Postnummer: 40530
Ort: Göteborg
Telefon: +46 31 786 1000
Hemsida: http://biomedicine.gu.se



Kort beskrivning av företaget:
The University of Gothenburg tackles society's challenges with diverse knowledge. 37 000 students and 6 000 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract scientists and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.

Titel: Researcher in molecular pathology

Beskrivning av arbetsuppgifter:
The Institute of Biomedicine is involved in both research and education. In both of these areas, we focus on fundamental knowledge of the living cell - what it consists of, how it works, how its function is directed by the genetic material, and how it interacts with various kinds of microorganisms. Using this knowledge, we try to elucidate the causes of diseases, and find new ways to diagnose and treat them. The Institute is composed of the following five departments: . The Department of Infectious Diseases . The Department of Microbiology and Immunology . The Department of Pathology and Genetics . The Department of Clinical Chemistry and Transfusion Medicine . The Department of Medical Biochemistry and Cell Biology Pathology involves studies on etiology and pathogenesis of diseases. The aim of this position as researcher is to study the pathogenesis of a new muscle glycogen storage disease (GSD XV) that we recently described. The disease is caused by inactivation of glycogenin-1, which functions as a primer for glycogen synthesis. It is a genetic, recessively inherited disorder that presents with cardiomyopathy with cardiac failure and/or skeletal myopathy with weakness and wasting. There is abnormal storage of glycogen in the cells, so-called polyglucosan. Not much is known about the normal expression of glycogenin-1 and glycogenin.2 in humans and the aims of the planned studies are to study the expression of gkycogenin-1 and glycogenin-2 in human organs and tissues in the normal situation and in patients with glycogenin -1 inactivation caused by mutations in the GYG1 gene.

Beskrivning av kvalifikationer:
PhD degree in a relevant area. Documented skills in methods relevant for the project including DNA/RNA extraction protein extraction, western blot, q-PCR, immunohistochemistry, protein interaction analyses, cell culturing and tansfection. Documented teaching skills and ability to collaborate are important in the evaluation of the applicant.


KONTAKTPERSON
Funktion: Professor/chief physician
Namn: Anders Oldfors
E-post: anders.oldfors@pathology.gu.se

Telefon: +46 31 342 2084